NANOBODY®(a registered trademark of Ablynx NV) molecules (Nbs), also referred to as
single domain-based VHHs, are antibody fragments derived from heavy-chain only IgG …

Cancer radio-immunotherapy, integrating external/internal radiation therapy with immuno-
oncology treatments, emerges in the current management of cancer. A growing number of …

Breast cancer is the most frequent type of malignancy in women worldwide, and drug
resistance to the available systemic therapies remains a major challenge. At the molecular …

Nanobodies are antibody fragments derived from camelids, naturally endowed with
properties like low molecular weight, high affinity and low immunogenicity, which contribute …

Camelidae derived single-domain antibodies (sdAbs), commonly known as nanobodies
(Nbs), are the smallest antibody fragments with full antigen-binding capacity. Owing to their …

Radioligand theranostics (RT) in oncology use cancer-type specific biomarkers and
molecular imaging (MI), including positron emission tomography (PET), single-photon …

Breast cancer is the most frequent invasive malignancy and the second major cause of
cancer death in female subjects mostly due to the considerable diagnostic delay and failure …

Purpose Early detection of hepatocellular carcinoma (HCC) remains a clinical challenge.
Glypican 3 (GPC3) is a proteoglycan highly specific for HCC and is a potential diagnostic …

Highlights•Nanobodies are ideal candidates for molecular imaging.•A key variable
determining the in vivo performance of a nanobody-derived molecular imaging tracer is the …

Targeted drug delivery is one of the attractive ways in which cancer treatment can
significantly reduce side effects. In the last two decades, the use of antibodies as a tool for …