Mesenchymal stem cells for regenerative medicine

Y Han, X Li, Y Zhang, Y Han, F Chang, J Ding - Cells, 2019 - mdpi.com
In recent decades, the biomedical applications of mesenchymal stem cells (MSCs) have
attracted increasing attention. MSCs are easily extracted from the bone marrow, fat, and …

Mesenchymal stem cell therapy for the treatment of inflammatory diseases: challenges, opportunities, and future perspectives

S Regmi, S Pathak, JO Kim, CS Yong… - European journal of cell …, 2019 - Elsevier
Mesenchymal stem cells (MSCs) are promising alternative agents for the treatment of
inflammatory disorders due to their immunomodulatory functions, and several clinical trials …

Bioactive glass-elicited stem cell-derived extracellular vesicles regulate M2 macrophage polarization and angiogenesis to improve tendon regeneration and functional …

H Xu, Y Zhu, AWT Hsiao, J Xu, W Tong, L Chang… - Biomaterials, 2023 - Elsevier
Effective countermeasures for tendon injury remains unsatisfactory. Mesenchymal stem cell-
derived extracellular vesicles (MSC-EVs)-based therapy via regulation of Mφ-mediated …

Tendon and ligament healing and current approaches to tendon and ligament regeneration

NL Leong, JL Kator, TL Clemens… - Journal of …, 2020 - Wiley Online Library
Ligament and tendon injuries are common problems in orthopedics. There is a need for
treatments that can expedite nonoperative healing or improve the efficacy of surgical repair …

The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke

CJ Cunningham, E Redondo-Castro… - Journal of Cerebral …, 2018 - journals.sagepub.com
Mesenchymal stem cells (MSCs) hold great potential as a regenerative therapy for stroke,
leading to increased repair and functional recovery in animal models of cerebral ischaemia …

Mesoporous silica as a versatile platform for cancer immunotherapy

TL Nguyen, Y Choi, J Kim - Advanced Materials, 2019 - Wiley Online Library
Immunotherapy has been recognized for decades as a promising therapeutic method for
cancer treatment. To enhance host immune responses against cancer, antigen‐presenting …

Extracellular vesicle-educated macrophages promote early achilles tendon healing

CS Chamberlain, AEB Clements, JA Kink, U Choi… - Stem Cells, 2019 - academic.oup.com
Tendon healing follows a complex series of coordinated events, which ultimately produces a
mechanically inferior tissue more scar-like than native tendon. More regenerative healing …

Immunoregulatory potential of mesenchymal stem cells following activation by macrophage-derived soluble factors

L Saldaña, F Bensiamar, G Vallés, FJ Mancebo… - Stem cell research & …, 2019 - Springer
Background Immunoregulatory capacity of mesenchymal stem cells (MSC) is triggered by
the inflammatory environment, which changes during tissue repair. Macrophages are …

[HTML][HTML] Exosomes derived from bone marrow stromal cells (BMSCs) enhance tendon-bone healing by regulating macrophage polarization

Y Shi, X Kang, Y Wang, X Bian, G He… - … medical journal of …, 2020 - ncbi.nlm.nih.gov
Background Inflammation after tendon-bone junction injury results in the formation of
excessive scar tissue and poor biomechanical properties. Recent research has shown that …

Biomaterials strategies to balance inflammation and tenogenesis for tendon repair

J Hou, R Yang, I Vuong, F Li, J Kong, HQ Mao - Acta biomaterialia, 2021 - Elsevier
Adult tendon tissue demonstrates a limited regenerative capacity, and the natural repair
process leaves fibrotic scar tissue with inferior mechanical properties. Surgical treatment is …