[HTML][HTML] Deep learning facilitates multi-data type analysis and predictive biomarker discovery in cancer precision medicine

VB Mathema, P Sen, S Lamichhane, M Orešič… - Computational and …, 2023 - Elsevier
Cancer progression is linked to gene-environment interactions that alter cellular
homeostasis. The use of biomarkers as early indicators of disease manifestation and …

Metabolomics of breast cancer: a review

R Subramani, S Poudel, KD Smith, A Estrada… - Metabolites, 2022 - mdpi.com
Breast cancer is the most commonly diagnosed cancer in women worldwide. Major
advances have been made towards breast cancer prevention and treatment. Unfortunately …

Metabolomics and transcriptomics based multi-omics integration reveals radiation-induced altered pathway networking and underlying mechanism

K Maan, R Baghel, S Dhariwal, A Sharma… - NPJ Systems Biology …, 2023 - nature.com
Recent advancement in integrated multi-omics has significantly contributed to many areas of
the biomedical field. Radiation research has also grasped uprising omics technologies in …

INTEGRATE: Model-based multi-omics data integration to characterize multi-level metabolic regulation

M Di Filippo, D Pescini, BG Galuzzi… - PLoS computational …, 2022 - journals.plos.org
Metabolism is directly and indirectly fine-tuned by a complex web of interacting regulatory
mechanisms that fall into two major classes. On the one hand, the expression level of the …

Multi-omics approach points to the importance of oxylipins metabolism in early-stage breast cancer

DV Chistyakov, MV Guryleva, ES Stepanova… - Cancers, 2022 - mdpi.com
Simple Summary On a system level, multi-omics approaches allow studying oxylipins,
metabolites of omega-3 or omega-6 polyunsaturated fatty acids. We compared the ultra-high …

[HTML][HTML] The Role of the Microbiome and of Radiotherapy-Derived Metabolites in Breast Cancer

L Herrera-Quintana, H Vázquez-Lorente, RCMC Silva… - Cancers, 2024 - mdpi.com
The gut microbiome has emerged as a crucial player in modulating cancer therapies,
including radiotherapy. In the case of breast cancer, the interplay between the microbiome …

Profiling canine mammary tumors: A potential model for studying human breast cancer

LM Gherman, P Chiroi, A Nuţu, C Bica… - The Veterinary …, 2024 - Elsevier
Despite all clinical progress recorded in the last decades, human breast cancer (HBC)
remains a major challenge worldwide both in terms of its incidence and its management …

Integrated Analysis of Transcriptome and Metabolome Provides Insight into Camellia oleifera Oil Alleviating Fat Accumulation in High-Fat Caenorhabditis elegans

L Liu, Q Kong, Z Xiang, X Kuang, H Wang… - International Journal of …, 2023 - mdpi.com
Camellia oil (CO) is a high medicinal and nutritional value edible oil. However, its ability to
alleviate fat accumulation in high-fat Caenorhabditis elegans has not been well elucidated …

Untargeted metabolic profiling of extracellular vesicles of SARS-CoV-2-infected patients shows presence of potent anti-inflammatory metabolites

FA Alzahrani, MR Shait Mohammed, S Alkarim… - International Journal of …, 2021 - mdpi.com
Extracellular vesicles (EVs) carry important biomolecules, including metabolites, and
contribute to the spread and pathogenesis of some viruses. However, to date, limited data …

Urolithin a and b alter cellular metabolism and induce metabolites associated with apoptosis in leukemic cells

AM Alzahrani, MR Shait Mohammed… - International journal of …, 2021 - mdpi.com
Leukemia is persistently a significant cause of illness and mortality worldwide. Urolithins,
metabolites of ellagic acid and ellagitannins produced by gut microbiota, showed better …