Despite the decline in death rate from breast cancer and recent advances in targeted
therapies and combinations for the treatment of metastatic disease, metastatic breast cancer …

The WT1 (Wilms' tumour 1) gene encodes a zinc finger transcription factor and RNA-binding
protein that direct the development of several organs and tissues. WT1 manifests both …

Genistein is an estrogenic soy-derived compound belonging to the isoflavone class and
shows anti-cancer effects. However, the specific cell apoptosis mechanisms of genistein …

Ovarian clear cell adenocarcinomas (OCCAs) account for< 5% of all ovarian malignancies.
Compared to other epithelial ovarian cancer (EOC) subtypes, when at an advanced stage …

Nuclear hormone receptors (NRs) are evolutionarily conserved ligand-dependent
transcription factors. They are essential for human life, mediating the actions of lipophilic …

The insulin-like growth factors, IGF-I and IGF-II are a familyof mitogenic polypeptides with
important roles in growth and differentiation. The biological actions of the IGFs are mediated …

Although Wilms' tumor gene 1 (WT1) was first cloned and identified as a tumor suppressor
gene in nephroblastoma, subsequent studies have demonstrated that it can also play an …

In antral follicles, transition of proliferative granulosa cells to estradiol-producing is critical for
proper oocyte maturation. MicroRNAs are noncoding RNAs that play important roles in …

IGF1R plays an important role in protection from apoptosis, regulation of cell growth,
differentiation and oncogenic transformation. IGF1R aberrations lead to intrauterine and …

The insulin-like growth factor-I receptor (IGF-IR) has an important role in normal mammary
gland growth and morphogenesis. In addition, the IGF-IR has been implicated in the …