Central nervous system (CNS) maintains a high level of metabolism, which leads to the
generation of large amounts of free radicals, and it is also one of the most vulnerable organs …

Excess production of reactive oxygen species in the brain has been implicated as a common
underlying risk factor for the pathogenesis of a number of neurodegenerative disorders …

Neurological disorders are prevalent worldwide. Cerebrovascular diseases (CVDs), which
account for 55% of all neurological diseases, are the leading cause of permanent disability …

Amyotrophic lateral sclerosis (ALS) is a rapid and fatal neurodegenerative disease, primarily
affecting upper and lower motor neurons. It is an extremely heterogeneous disease in both …

BACKGROUND AND PURPOSE Glutamate transporters play a major role in maintaining
brain homeostasis and the astrocytic transporters, EAAT1 and EAAT2, are functionally …

Astrocytes are a target for regenerative neurobiology because in brain injury their phenotype
arbitrates brain integrity, neuronal death and subsequent repair and reconstruction. We …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder in which
the loss of upper and lower motor neurons produces progressive weakness and eventually …

This study aims to develop a cellular metabolomics model that reproduces the
pathophysiological conditions found in amyotrophic lateral sclerosis in order to improve …

Inhibitors of Rho kinase (ROCK) have potential for management of neurological disorders by
inhibition of glial scarring. Since astrocytes play key roles in brain physiology and pathology …

Reactive gliosis has been implicated in both inflammatory and neurodegenerative diseases.
However, mechanisms by which astrocytic activation affects synaptic efficacy have been …