In all eukaryotes, morphogenesis of the microtubule cytoskeleton into a bipolar spindle is
required for the faithful transmission of the genome to the two daughter cells during division …

The mitotic spindle assembles to a steady-state length at metaphase through the integrated
action of molecular mechanisms that generate and respond to mechanical forces. While …

Spindle assembly required during mitosis depends on microtubule polymerization. We
demonstrate that the evolutionarily conserved low-complexity protein, BuGZ, undergoes …

Background The recent completion of the Drosophila melanogaster genomic sequence to
high quality and the availability of a greatly expanded set of Drosophila cDNA sequences …

▪ Abstract Spindle microtubules interact with mitotic chromosomes, binding to their
kinetochores to generate forces that are important for accurate chromosome segregation …

Insect genomes contain larger blocks of conserved gene order (microsynteny) than would
be expected under a random breakage model of chromosome evolution. We present …

The midzone is the domain of the mitotic spindle that maintains spindle bipolarity during
anaphase and generates forces required for spindle elongation (anaphase B). Although …

Drosophila's importance as a model organism made it an obvious choice to be among the
first genomes sequenced, and the Release 1 sequence of the euchromatic portion of the …

We used fluorescent speckle microscopy to probe the dynamics of the mitotic kinesin Eg5 in
Xenopus extract spindles, and compared them to microtubule dynamics. We found …

The embryonic cuticle of Drosophila melanogaster is deposited by the epidermal epithelium
during stage 16 of development. This tough, waterproof layer is essential for maintaining the …