High frequency of Plasmodium falciparum chloroquine resistance marker (pfcrt T76 mutation) in Yemen: An urgent need to re-examine malaria drug policy

AM Al-Mekhlafi, MAK Mahdy, HM Al-Mekhlafi… - Parasites & vectors, 2011 - Springer
Background Malaria remains a significant health problem in Yemen with Plasmodium
falciparum being the predominant species which is responsible for 90% of the malaria …

Genetic diversity of Plasmodium falciparum and distribution of drug resistance haplotypes in Yemen

S Al-Hamidhi, MAK Mahdy, Z Al-Hashami, H Al-Farsi… - Malaria Journal, 2013 - Springer
Background Despite evident success of malaria control in many sites in the Arabian
Peninsula, malaria remains endemic in a few spots, in Yemen and south-west of Saudi …

In Vitro Chloroquine Resistance in Plasmodium falciparum Isolates from Tertiary Care Hospital

F Shujatullah, HM Khan, A Khatoon… - Malaria Research …, 2012 - Wiley Online Library
Chloroquine (CQ) has been the mainstay of treatment of malaria for decades. This cost‐
effective and safe drug has become ineffective for treatment of falciparum malaria in many …

Sustained efficacy of artesunate-sulfadoxine-pyrimethamine against Plasmodium falciparum in Yemen and a renewed call for an adjunct single dose primaquine to …

WM Atroosh, HM Al-Mekhlafi, G Snounou, A Al-Jasari… - Malaria Journal, 2016 - Springer
Abstract Background In Yemen, artesunate plus sulfadoxine-pyrimethamine (AS+ SP) has
been used as first-line treatment for uncomplicated falciparum malaria, which accounts for …

Survey of chloroquine-resistant mutations in the Plasmodium falciparum pfcrt and pfmdr-1 genes in Hadhramout, Yemen

OAA Bamaga, MAK Mahdy, YAL Lim - Acta Tropica, 2015 - Elsevier
Malaria is still a major public health problem in Yemen. More than 95% of the malaria cases
are due to Plasmodium‎ falciparum‎. Recently in Yemen, the antimalarial treatment policy was …

The prospect of malaria elimination in the Arabian Peninsula: a population genetic approach

S Al-Hamidhi, MAK Mahdy, MA Idris… - Infection, Genetics and …, 2014 - Elsevier
Abstract Background In the Arabian Peninsula malaria control is progressing steadily,
backed by adequate logistic and political support. As a result, transmission has been …

Different patterns of pfcrt and pfmdr1 polymorphism in Plasmodium falciparum isolates from Tehama region, Yemen

WM Atroosh, HM Al-Mekhlafi, A Al-Jasari, H Sady… - PeerJ, 2016 - peerj.com
Introduction. Despite the efforts of the malaria control programme, malaria morbidity is still a
common health problem in Yemen, with 60% of the population at risk. Plasmodium …

Mutant Plasmodium falciparum chloroquine resistance transporter in Hodeidah, Yemen: association with parasitologic indices and treatment-seeking behaviors

R Abdul-Ghani, HF Farag, AF Allam, SM Shawky… - Acta tropica, 2013 - Elsevier
Malaria still represents a major health problem in Yemen, particularly in Hodeidah, despite
continuing efforts to eliminate it. With the absence of clinically proven vaccines …

Pharmacodynamics of antimalarial chemotherapy

K Na-Bangchang - Expert Review of Clinical Pharmacology, 2009 - Taylor & Francis
Malaria chemotherapy is under constant threat from the emergence and spread of multidrug
resistance of Plasmodium falciparum. Resistance has been observed to almost all currently …

Prevailing Plasmodium falciparum dihydrofolate reductase 108-asparagine in Hodeidah, Yemen: a questionable sulfadoxine–pyrimethamine partner within the …

R Abdul-Ghani, HF Farag, AF Allam, SM Shawky - Acta tropica, 2014 - Elsevier
Given that the evolution and spread of resistance to sulfadoxine–pyrimethamine (SP) have
been documented at a quick pace worldwide, the present study investigated the mutant …