In order to fully understand any complex biochemical system from a mechanistic point of
view, it is necessary to have access to the three-dimensional structures of the molecular …

The establishment of cell polarity is critical for the development of many organisms and for
the function of many cell types. A large number of studies of diverse organisms from yeast to …

Background Metazoan multicellularity is rooted in mechanisms of cell adhesion, signaling,
and differentiation that first evolved in the progenitors of metazoans. To reconstruct the …

Septins are GTP-binding proteins that assemble into homo-and hetero-oligomers and
filaments. Although they have key roles in various cellular processes, little is known …

Septins comprise a conserved family of proteins that are found primarily in fungi and
animals. These GTP-binding proteins have several roles during cell division, cytoskeletal …

Microscopy of fluorescent fusion proteins and genetic dependencies show that fission yeast
assemble and constrict a cytokinetic contractile ring in a precisely timed, sequential order …

A specialized cortical domain is organized by the septins at the necks of budding yeast cells.
Recent findings suggest that this domain serves as a diffusion barrier and also as a local cell …

Septins are an evolutionarily conserved group of GTP‐binding and filament‐forming
proteins that belong to the large superclass of P‐loop GTPases. While originally discovered …

Eukaryotic cells from neurons and epithelial cells to unicellular fungi frequently rely on
cellular appendages such as axons, dendritic spines, cilia, and buds for their biology. The …

Septins are a conserved family of polymerizing guanine nucleotide binding proteins
associated with diverse processes in dividing and non-dividing cells. In humans, 12 septin …