▪ Abstract Cells in the immune and nervous systems communicate through informational
synapses. The two-dimensional chemistry underlying the process of synapse formation is …

Cell membranes interact via anchored receptor and ligand molecules. Central questions on
cell adhesion concern the binding affinity of these membrane-anchored molecules, the …

The T-cell receptor (TCR) interacts with peptide-major histocompatibility complexes (pMHC)
to discriminate pathogens from self-antigens and trigger adaptive immune responses. Direct …

Antigen recognition by the T cell receptor (TCR) of CD4+ T cells can be greatly enhanced by
the coreceptor CD4. Yet, understanding of the molecular mechanism is hindered by the ultra …

As adhesion molecules, integrins connect a cell to its environment and transduce signals
across the membrane. Their different functional states correspond to distinct conformations …

Surface presentation of adhesion receptors influences cell adhesion, although the
mechanisms underlying these effects are not well understood. We used a micropipette …

CD8 plays an important role in facilitating TCR-MHC interaction, promoting Ag recognition,
and initiating T cell activation. MHC-CD8 binding kinetics have been measured in three …

Interactions between surface-anchored receptors and ligands mediate cell–cell and cell–
environment communications in many biological processes. Molecular interactions across …

Two‐dimensional (2 D) kinetic analysis directly measures molecular interactions at cell–cell
junctions, thereby incorporating inherent cellular effects. By comparison, three‐dimensional …

We present direct evidence that the N-glycosylation state of neural cadherin impacts the
intrinsic kinetics of cadherin-mediated intercellular binding. Micropipette manipulation …