Spatial descriptions of radiotherapy dose: normal tissue complication models and statistical associations

MA Ebert, S Gulliford, O Acosta… - Physics in Medicine …, 2021 - iopscience.iop.org
For decades, dose-volume information for segmented anatomy has provided the essential
data for correlating radiotherapy dosimetry with treatment-induced complications. Dose …

rtdsm—An open‐source software for radiotherapy dose‐surface map generation and analysis

HM Patrick, J Kildea - Medical physics, 2022 - Wiley Online Library
Background Dose‐outcome studies in radiation oncology have historically excluded spatial
information due to dose‐volume histograms being the most dominant source of dosimetric …

[HTML][HTML] Associations between voxel-level accumulated dose and rectal toxicity in prostate radiotherapy

LEA Shelley, MPF Sutcliffe, SJ Thomas… - Physics and Imaging in …, 2020 - Elsevier
Abstract Background and Purpose Associations between dose and rectal toxicity in prostate
radiotherapy are generally poorly understood. Evaluating spatial dose distributions to the …

Local dose effects for late gastrointestinal toxicity after hypofractionated and conventionally fractionated modern radiotherapy for prostate cancer in the HYPRO trial

WD Heemsbergen, L Incrocci, FJ Pos… - Frontiers in …, 2020 - frontiersin.org
Purpose: Late gastrointestinal (GI) toxicity after radiotherapy for prostate cancer may have
significant impact on the cancer survivor's quality of life. To date, little is known about local …

Association of radiation-induced normal tissue toxicity with a high genetic risk for rheumatoid arthritis

A Mcwilliam, D Marshall, SL Kerns… - JNCI: Journal of the …, 2025 - academic.oup.com
Purpose Overlapping genes are involved with rheumatoid arthritis (RA) and DNA repair
pathways. Therefore, we hypothesised that patients with a high polygenic risk score (PRS) …

[HTML][HTML] Dose-volume analysis of planned versus accumulated dose as a predictor for late gastrointestinal toxicity in men receiving radiotherapy for high-risk prostate …

ALK Ong, K Knight, V Panettieri, M Dimmock… - Physics and Imaging in …, 2022 - Elsevier
Background and purpose Significant dose deviations have been reported between planned
(DP) and accumulated (DA) dose in prostate radiotherapy. This study aimed to develop …

[HTML][HTML] Effect of three-dimensional conformal radiotherapy and intensity-modulated radiotherapy on parotid gland function and quality of life in patients with …

L Zheng, L Tong, F Du, H Ren… - American journal of …, 2021 - ncbi.nlm.nih.gov
Objective: To investigate the effects of three-dimensional conformal radiotherapy (3DCRT)
and intensity-modulated radiotherapy (IMRT) on parotid gland function and quality of life in …

More than one way to skin a dose volume: the impact of dose-surface map calculation approach on study reproducibility

HM Patrick, J Kildea - Physics in Medicine & Biology, 2024 - iopscience.iop.org
Objective. Dose-surface maps (DSMs) provide spatial representations of the radiation dose
to organ surfaces during radiotherapy and are a valuable tool for identifying dose deposition …

[HTML][HTML] Patient-reported acute GI symptoms in locally advanced cervical cancer patients correlate with rectal dose

DMW Reijtenbagh, J Godart, JWM Mens… - Radiotherapy and …, 2020 - Elsevier
Background and purpose To investigate relationships between patient-reported acute gastro-
intestinal symptoms in a locally advanced cervical cancer (LACC) prospective cohort and …

Patient-reported persistent symptoms after radiotherapy and association with quality of life for prostate cancer survivors

S Spampinato, T Rancati, JM Waskiewicz… - Acta …, 2023 - Taylor & Francis
Purpose To evaluate the persistence of symptoms after radiotherapy (RT) for localised
prostate cancer (PCa) and the association with quality of life (QOL). Materials and methods …