Understanding nanoparticle endocytosis to improve targeting strategies in nanomedicine

MS de Almeida, E Susnik, B Drasler… - Chemical society …, 2021 - pubs.rsc.org
Nanoparticles (NPs) have attracted considerable attention in various fields, such as
cosmetics, the food industry, material design, and nanomedicine. In particular, the fast …

Tutorial: guidance for quantitative confocal microscopy

J Jonkman, CM Brown, GD Wright, KI Anderson… - Nature protocols, 2020 - nature.com
When used appropriately, a confocal fluorescence microscope is an excellent tool for
making quantitative measurements in cells and tissues. The confocal microscope's ability to …

Deciphering the catalytic mechanism of superoxide dismutase activity of carbon dot nanozyme

W Gao, J He, L Chen, X Meng, Y Ma, L Cheng… - Nature …, 2023 - nature.com
Nanozymes with superoxide dismutase (SOD)-like activity have attracted increasing interest
due to their ability to scavenge superoxide anion, the origin of most reactive oxygen species …

Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired

W Liang, S Sagar, R Ravindran, RH Najor… - Nature …, 2023 - nature.com
Mitochondrial quality control is critical for cardiac homeostasis as these organelles are
responsible for generating most of the energy needed to sustain contraction. Dysfunctional …

Mitochondrial‐targeted delivery of polyphenol‐mediated antioxidases complexes against pyroptosis and inflammatory diseases

J Zhang, B Gao, B Ye, Z Sun, Z Qian, L Yu… - Advanced …, 2023 - Wiley Online Library
Excess accumulation of mitochondrial reactive oxygen species (mtROS) is a key target for
inhibiting pyroptosis‐induced inflammation and tissue damage. However, targeted delivery …

Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries

AR Banday, ML Stanifer, O Florez-Vargas… - Nature …, 2022 - nature.com
Abstract The chr12q24. 13 locus encoding OAS1–OAS3 antiviral proteins has been
associated with coronavirus disease 2019 (COVID-19) susceptibility. Here, we report …

[HTML][HTML] Structure of the lysosomal mTORC1–TFEB–Rag–Ragulator megacomplex

Z Cui, G Napolitano, MEG de Araujo, A Esposito… - Nature, 2023 - nature.com
The transcription factor TFEB is a master regulator of lysosomal biogenesis and autophagy.
The phosphorylation of TFEB by the mechanistic target of rapamycin complex 1 (mTORC1) …

Nanoparticle charge and size control foliar delivery efficiency to plant cells and organelles

P Hu, J An, MM Faulkner, H Wu, Z Li, X Tian… - ACS …, 2020 - ACS Publications
Fundamental and quantitative understanding of the interactions between nanoparticles and
plant leaves is crucial for advancing the field of nanoenabled agriculture. Herein, we …

Autonomous metal-organic framework nanorobots for active mitochondria-targeted cancer therapy

X Peng, S Tang, D Tang, D Zhou, Y Li, Q Chen… - Science …, 2023 - science.org
Nanorobotic manipulation to access subcellular organelles remains unmet due to the
challenge in achieving intracellular controlled propulsion. Intracellular organelles, such as …

Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels

VS Peche, TA Pietka, M Jacome-Sosa… - Nature …, 2023 - nature.com
Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs
transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of …