Background Physical activity has a protective effect against cardiovascular disease (CVD) in
high-income countries, where physical activity is mainly recreational, but it is not known if …

In a long term clinical trial to evaluate a new treatment, quite often each study subject may
experience a number of 'failures' that correspond to repeated occurrences of the same type …

PURPOSE SARS-CoV-2 (COVID-19) is a systemic infection. Patients with cancer are
immunocompromised and may be vulnerable to COVID-related morbidity and mortality. The …

Many randomized trials evaluate an intervention effect on time‐to‐event outcomes.
Individual participant data (IPD) from such trials can be obtained and combined in a so …

This book serves as an introductory guide for students and analysts who need to work with
survival time data. The minimum prerequisites are basic applied courses in linear regression …

Importance Relatives of patients with systemic lupus erythematosus (SLE) appear to be at
higher risk of SLE and other autoimmune diseases, but estimates of individual familial risks …

The Cox Model Page 1 3 The Cox Model 3.1 Introduction and notation The Cox proportional
hazards model [36] has become by a wide margin the most used procedure for modeling the …

Although powerful and flexible, the method of generalized linear models (GLM) is limited in
its ability to accurately deal with longitudinal and clustered data. Developed specifically to …

The concept of frailty offers a convenient way to introduce unobserved heterogeneity and
associations into models for survival data. In its simplest form, frailty is an unobserved …

Here is an accessible, up-to-date guide to event history analysis for researchers and
advanced students in the social sciences. The foundational principles of event history …