The alpha keto amide moiety as a privileged motif in medicinal chemistry: current insights and emerging opportunities
M Robello, E Barresi, E Baglini, S Salerno… - Journal of Medicinal …, 2021 - ACS Publications
Over the years, researchers in drug discovery have taken advantage of the use of privileged
structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many …
structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many …
Short cationic peptidomimetic antimicrobials
The rapid growth of antimicrobial resistance against several frontline antibiotics has
encouraged scientists worldwide to develop new alternatives with unique mechanisms of …
encouraged scientists worldwide to develop new alternatives with unique mechanisms of …
The use of tethered bilayer lipid membranes to identify the mechanisms of antimicrobial peptide interactions with lipid bilayers
A Alghalayini, A Garcia, T Berry, CG Cranfield - Antibiotics, 2019 - mdpi.com
This review identifies the ways in which tethered bilayer lipid membranes (tBLMs) can be
used for the identification of the actions of antimicrobials against lipid bilayers. Much of the …
used for the identification of the actions of antimicrobials against lipid bilayers. Much of the …
Exploring the efficacy of peptides and mimics against Influenza A Virus, Adenovirus, and murine norovirus
The ongoing battle against viral pandemics continues, with the possibility of future
outbreaks. The search for effective antiviral compounds that can combat a diverse range of …
outbreaks. The search for effective antiviral compounds that can combat a diverse range of …
Biophysical characterization of LTX-315 anticancer peptide interactions with model membrane platforms: effect of membrane surface charge
LTX-315 is a clinical-stage, anticancer peptide therapeutic that disrupts cancer cell
membranes. Existing mechanistic knowledge about LTX-315 has been obtained from cell …
membranes. Existing mechanistic knowledge about LTX-315 has been obtained from cell …
Lipid membrane interactions of the cationic antimicrobial peptide chimeras melimine and cys-melimine
Melimine and its derivatives are synthetic chimeric antimicrobial agents based on protamine
and melittin. The binding of solubilized melimine and its derivative, with a cysteine on N …
and melittin. The binding of solubilized melimine and its derivative, with a cysteine on N …
Design, Synthesis and Biological Evaluation of Biphenylglyoxamide-Based Small Molecular Antimicrobial Peptide Mimics as Antibacterial Agents
There has been an increasing interest in the development of antimicrobial peptides (AMPs)
and their synthetic mimics as a novel class of antibiotics to overcome the rapid emergence of …
and their synthetic mimics as a novel class of antibiotics to overcome the rapid emergence of …
Polyphenylglyoxamide-based amphiphilic small molecular peptidomimetics as antibacterial agents with anti-biofilm activity
The rapid emergence of drug-resistant bacteria is a major global health concern.
Antimicrobial peptides (AMPs) and peptidomimetics have arisen as a new class of …
Antimicrobial peptides (AMPs) and peptidomimetics have arisen as a new class of …
Modified Chemoselective Reduction and Consecutive Regioselective Deuteration Reaction Catalyzed by B(C6F5)3
SY Park, J Kim, HM Ko - The Journal of Organic Chemistry, 2023 - ACS Publications
An efficient chemoselective reduction of isatin derivatives using catalyst B (C6F5) 3,
benzyldimethylsilane, and H2O is described. Notably, a small amount of water is shown to …
benzyldimethylsilane, and H2O is described. Notably, a small amount of water is shown to …
Design, Synthesis and bioevaluation of highly functionalized 1, 2, 3-triazole-guanidine conjugates as anti-inflammatory and antioxidant agents
MA Siddiqui, AA Nagargoje, MH Shaikh… - Polycyclic Aromatic …, 2023 - Taylor & Francis
In search of new biologically potent molecules a small focused library of new guanidine-1, 2,
3-triazole hybrid derivatives were synthesized via Organocatalytic enolate-mediated azide …
3-triazole hybrid derivatives were synthesized via Organocatalytic enolate-mediated azide …