RNA sequencing: the teenage years
Over the past decade, RNA sequencing (RNA-seq) has become an indispensable tool for
transcriptome-wide analysis of differential gene expression and differential splicing of …
transcriptome-wide analysis of differential gene expression and differential splicing of …
Co-transcriptional gene regulation in eukaryotes and prokaryotes
M Shine, J Gordon, L Schärfen, D Zigackova… - … Reviews Molecular Cell …, 2024 - nature.com
Many steps of RNA processing occur during transcription by RNA polymerases. Co-
transcriptional activities are deemed commonplace in prokaryotes, in which the lack of …
transcriptional activities are deemed commonplace in prokaryotes, in which the lack of …
H3K4me3 regulates RNA polymerase II promoter-proximal pause-release
Trimethylation of histone H3 lysine 4 (H3K4me3) is associated with transcriptional start sites
and has been proposed to regulate transcription initiation,. However, redundant functions of …
and has been proposed to regulate transcription initiation,. However, redundant functions of …
Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1
It remains unclear why acute depletion of CTCF (CCCTC-binding factor) and cohesin only
marginally affects expression of most genes despite substantially perturbing three …
marginally affects expression of most genes despite substantially perturbing three …
Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks
The DNA damage response (DDR) preserves genomic integrity. Small non-coding RNAs
termed DDRNAs are generated at DNA double-strand breaks (DSBs) and are critical for …
termed DDRNAs are generated at DNA double-strand breaks (DSBs) and are critical for …
Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors
Damage-induced long non-coding RNAs (dilncRNA) synthesized at DNA double-strand
breaks (DSBs) by RNA polymerase II are necessary for DNA-damage-response (DDR) focus …
breaks (DSBs) by RNA polymerase II are necessary for DNA-damage-response (DDR) focus …
DDM1-mediated R-loop resolution and H2A. Z exclusion facilitates heterochromatin formation in Arabidopsis
J Zhou, X Lei, S Shafiq, W Zhang, Q Li, K Li, J Zhu… - Science …, 2023 - science.org
Programmed constitutive heterochromatin silencing is essential for eukaryotic genome
regulation, yet the initial step of this process is ambiguous. A large proportion of R-loops …
regulation, yet the initial step of this process is ambiguous. A large proportion of R-loops …
BRCA2 controls DNA: RNA hybrid level at DSBs by mediating RNase H2 recruitment
DNA double-strand breaks (DSBs) are toxic DNA lesions, which, if not properly repaired,
may lead to genomic instability, cell death and senescence. Damage-induced long non …
may lead to genomic instability, cell death and senescence. Damage-induced long non …
[HTML][HTML] Distinctive patterns of transcription and RNA processing for human lincRNAs
Numerous long intervening noncoding RNAs (lincRNAs) are generated from the mammalian
genome by RNA polymerase II (Pol II) transcription. Although multiple functions have been …
genome by RNA polymerase II (Pol II) transcription. Although multiple functions have been …
Widespread RNA editing dysregulation in brains from autistic individuals
SS Tran, HI Jun, JH Bahn, A Azghadi… - Nature …, 2019 - nature.com
Transcriptomic analyses of postmortem brains have begun to elucidate molecular
abnormalities in autism spectrum disorder (ASD). However, a crucial pathway involved in …
abnormalities in autism spectrum disorder (ASD). However, a crucial pathway involved in …