Proton-sensitive cation channels and ion exchangers in ischemic brain injury: new therapeutic targets for stroke?
Ischemic brain injury results from complicated cellular mechanisms. The present therapy for
acute ischemic stroke is limited to thrombolysis with the recombinant tissue plasminogen …
acute ischemic stroke is limited to thrombolysis with the recombinant tissue plasminogen …
NHE-1: still a viable therapeutic target
M Karmazyn - Journal of molecular and cellular cardiology, 2013 - Elsevier
The concept of Nasingle bond H exchange (NHE) involvement in cardiac pathology has
been espoused for decades and supported by a plethora of experimental studies …
been espoused for decades and supported by a plethora of experimental studies …
Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function
Background Chronic cerebral hypoperfusion (CCH) causes white matter damage and
cognitive impairment, in which astrogliosis is the major pathology. However, underlying …
cognitive impairment, in which astrogliosis is the major pathology. However, underlying …
A combination antioxidant therapy to inhibit NOX2 and activate Nrf2 decreases secondary brain damage and improves functional recovery after traumatic brain injury
Uncontrolled oxidative stress contributes to the secondary neuronal death that promotes
long-term neurological dysfunction following traumatic brain injury (TBI). Surprisingly, both …
long-term neurological dysfunction following traumatic brain injury (TBI). Surprisingly, both …
Astrocytes in oligodendrocyte lineage development and white matter pathology
J Li, L Zhang, Y Chu, M Namaka, B Deng… - Frontiers in cellular …, 2016 - frontiersin.org
White matter is primarily composed of myelin and myelinated axons. Structural and
functional completeness of myelin is critical for the reliable and efficient transmission of …
functional completeness of myelin is critical for the reliable and efficient transmission of …
Developmental differences in microglia morphology and gene expression during normal brain development and in response to hypoxia-ischemia
P Cengiz, D Zafer, JH Chandrashekhar… - Neurochemistry …, 2019 - Elsevier
Background Neuroinflammation plays an important role in ischemic brain injury and
recovery, however the interplay between brain development and the neuroinflammatory …
recovery, however the interplay between brain development and the neuroinflammatory …
Identification of novel circulatory microRNA signatures linked to patients with ischemic stroke
MicroRNAs (miRNAs) are involved in growth, development, and occurrence and
progression of many diseases. MiRNA-mediated post-transcriptional regulation is poorly …
progression of many diseases. MiRNA-mediated post-transcriptional regulation is poorly …
The Role of Na+/Ca2+ Exchanger Subtypes in Neuronal Ischemic Injury
B Shenoda - Translational stroke research, 2015 - Springer
Abstract The Na+/Ca 2+ exchanger (NCX) plays an important role in the maintenance of
Na+ and Ca 2+ homeostasis in most cells including neurons under physiological and …
Na+ and Ca 2+ homeostasis in most cells including neurons under physiological and …
Na+/H+ Exchangers and Intracellular pH in Perinatal Brain Injury
C Uria-Avellanal, NJ Robertson - Translational stroke research, 2014 - Springer
Encephalopathy consequent on perinatal hypoxia–ischemia occurs in 1–3 per 1,000 term
births in the UK and frequently leads to serious and tragic consequences that devastate lives …
births in the UK and frequently leads to serious and tragic consequences that devastate lives …
The anti-parkinsonian drug zonisamide reduces neuroinflammation: role of microglial Nav 1.6
MM Hossain, B Weig, K Reuhl, M Gearing, LJ Wu… - Experimental …, 2018 - Elsevier
Abstract Parkinson's disease (PD), the second most common age-related progressive
neurodegenerative disorder, is characterized by dopamine depletion and the loss of …
neurodegenerative disorder, is characterized by dopamine depletion and the loss of …