Clocks, cancer, and chronochemotherapy

A Sancar, RN Van Gelder - Science, 2021 - science.org
BACKGROUND The core of the mammalian circadian clock mechanism is a time-delayed
transcription-translation feedback loop (TTFL), which influences the transcription and …

Transcriptional architecture of the mammalian circadian clock

JS Takahashi - Nature Reviews Genetics, 2017 - nature.com
Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …

Shift work: disrupted circadian rhythms and sleep—implications for health and well-being

SM James, KA Honn, S Gaddameedhi… - Current sleep medicine …, 2017 - Springer
Abstract Purpose of Review Our 24/7 society is dependent on shift work, despite mounting
evidence for negative health outcomes from sleep displacement due to shift work. This …

Circadian rhythms and cancers: the intrinsic links and therapeutic potentials

L Zhou, Z Zhang, E Nice, C Huang, W Zhang… - Journal of Hematology & …, 2022 - Springer
The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …

Systems chronotherapeutics

A Ballesta, PF Innominato, R Dallmann, DA Rand… - Pharmacological …, 2017 - Elsevier
Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

Cancer and the circadian clock

AA Shafi, KE Knudsen - Cancer research, 2019 - AACR
The circadian clock is a master regulator of mammalian physiology, regulating daily
oscillations of crucial biological processes and behaviors. Notably, circadian disruption has …

Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs

A Yimit, O Adebali, A Sancar, Y Jiang - Nature communications, 2019 - nature.com
The platinum-based drug cisplatin is a widely used first-line therapy for several cancers.
Cisplatin interacts with DNA mainly in the form of Pt-d (GpG) di-adduct, which stalls cell …

When less may be more: calorie restriction and response to cancer therapy

CH O'Flanagan, LA Smith, SB McDonell, SD Hursting - BMC medicine, 2017 - Springer
Calorie restriction (CR) extends lifespan and has been shown to reduce age-related
diseases including cancer, diabetes, and cardiovascular and neurodegenerative diseases …

Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture).

A Sancar - Angewandte Chemie International Edition, 2016 - search.ebscohost.com
The article presents the result of a study which examined DNA repair through photolyase in
Escherichia coli and nucleotide excision repair in both microorganism and humans. The …

Chronotherapy: circadian rhythms and their influence in cancer therapy

A Amiama-Roig, EM Verdugo-Sivianes, A Carnero… - Cancers, 2022 - mdpi.com
Simple Summary Living organisms present rhythmic fluctuations every 24 h in their behavior
and metabolism to anticipate changes in the environment. These fluctuations are controlled …