Clocks, cancer, and chronochemotherapy
A Sancar, RN Van Gelder - Science, 2021 - science.org
BACKGROUND The core of the mammalian circadian clock mechanism is a time-delayed
transcription-translation feedback loop (TTFL), which influences the transcription and …
transcription-translation feedback loop (TTFL), which influences the transcription and …
Transcriptional architecture of the mammalian circadian clock
JS Takahashi - Nature Reviews Genetics, 2017 - nature.com
Circadian clocks are endogenous oscillators that control 24-hour physiological and
behavioural processes in organisms. These cell-autonomous clocks are composed of a …
behavioural processes in organisms. These cell-autonomous clocks are composed of a …
Shift work: disrupted circadian rhythms and sleep—implications for health and well-being
Abstract Purpose of Review Our 24/7 society is dependent on shift work, despite mounting
evidence for negative health outcomes from sleep displacement due to shift work. This …
evidence for negative health outcomes from sleep displacement due to shift work. This …
Circadian rhythms and cancers: the intrinsic links and therapeutic potentials
The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …
Systems chronotherapeutics
Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …
Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs
The platinum-based drug cisplatin is a widely used first-line therapy for several cancers.
Cisplatin interacts with DNA mainly in the form of Pt-d (GpG) di-adduct, which stalls cell …
Cisplatin interacts with DNA mainly in the form of Pt-d (GpG) di-adduct, which stalls cell …
When less may be more: calorie restriction and response to cancer therapy
CH O'Flanagan, LA Smith, SB McDonell, SD Hursting - BMC medicine, 2017 - Springer
Calorie restriction (CR) extends lifespan and has been shown to reduce age-related
diseases including cancer, diabetes, and cardiovascular and neurodegenerative diseases …
diseases including cancer, diabetes, and cardiovascular and neurodegenerative diseases …
Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture).
A Sancar - Angewandte Chemie International Edition, 2016 - search.ebscohost.com
The article presents the result of a study which examined DNA repair through photolyase in
Escherichia coli and nucleotide excision repair in both microorganism and humans. The …
Escherichia coli and nucleotide excision repair in both microorganism and humans. The …
Chronotherapy: circadian rhythms and their influence in cancer therapy
A Amiama-Roig, EM Verdugo-Sivianes, A Carnero… - Cancers, 2022 - mdpi.com
Simple Summary Living organisms present rhythmic fluctuations every 24 h in their behavior
and metabolism to anticipate changes in the environment. These fluctuations are controlled …
and metabolism to anticipate changes in the environment. These fluctuations are controlled …