Tetraspanins are molecular scaffolds that distribute proteins into highly organized
microdomains consisting of adhesion, signaling, and adaptor proteins. Many reports have …

T-cell acute lymphoblastic leukemia (T-ALL) accounts for 15% and 25% of total childhood
and adult ALL cases, respectively. During T-ALL, patients are at risk of organ infiltration by …

Long-term survival rates in childhood acute lymphoblastic leukemia (ALL) are currently
above 85% due to huge improvements in treatment. However, 15-20% of children still …

Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by the
malignant clonal expansion of lymphoid hematopoietic precursors. It is regulated by various …

Pancreatic cancer (PaCa) has the highest death rate and incidence is increasing. Poor
prognosis is due to late diagnosis and early metastatic spread, which is ascribed to a minor …

Immune receptors are not randomly distributed at the plasma membrane of lymphocytes but
are segregated into specialized domains that function as platforms to initiate signalling, as …

CD9 is a crucial regulator of cell adhesion in the immune system and plays important
physiological roles in hematopoiesis, blood coagulation or viral and bacterial infections. It is …

The trafficking of neoplastic cells represents a key process that contributes to progression of
hematologic malignancies. Diapedesis of neoplastic cells across endothelium and …

The outcomes of children with acute lymphoblastic leukemia (ALL) have been incrementally
improved with risk-directed chemotherapy but therapy responses remain heterogeneous …

Acute lymphoblastic leukaemia (ALL) is the most common cancer diagnosed in children and
adolescents. Approximately 70% of patients survive> 5-years following diagnosis, however …