Targeting vascular inflammation through emerging methods and drug carriers
Acute inflammation is a common dangerous component of pathogenesis of many prevalent
conditions with high morbidity and mortality including sepsis, thrombosis, acute respiratory …
conditions with high morbidity and mortality including sepsis, thrombosis, acute respiratory …
The role of the cell surface glycocalyx in drug delivery to and through the endothelium
Cell membranes are key interfaces where materials engineering meets biology. Traditionally
regarded as just the location of receptors regulating the uptake of molecules, we now know …
regarded as just the location of receptors regulating the uptake of molecules, we now know …
Effect of flow on targeting and penetration of angiopep-decorated nanoparticles in a microfluidic model blood-brain barrier
I Papademetriou, E Vedula, J Charest, T Porter - PloS one, 2018 - journals.plos.org
The blood-brain barrier (BBB) limits transport of nanoparticles from the circulation to the
brain parenchyma. Angiopep-2, a peptide which functions as a brain transport vector, can be …
brain parenchyma. Angiopep-2, a peptide which functions as a brain transport vector, can be …
Cell and nanoparticle transport in tumour microvasculature: the role of size, shape and surface functionality of nanoparticles
Through nanomedicine, game-changing methods are emerging to deliver drug molecules
directly to diseased areas. One of the most promising of these is the targeted delivery of …
directly to diseased areas. One of the most promising of these is the targeted delivery of …
Reduction of nanoparticle avidity enhances the selectivity of vascular targeting and PET detection of pulmonary inflammation
Targeting nanoparticles (NPs) loaded with drugs and probes to precise locations in the body
may improve the treatment and detection of many diseases. Generally, to achieve targeting …
may improve the treatment and detection of many diseases. Generally, to achieve targeting …
Nanoparticle localization in blood vessels: dependence on fluid shear stress, flow disturbances, and flow-induced changes in endothelial physiology
Nanoparticles in the bloodstream are subjected to complex fluid forces as they move
through the curves and branches of healthy or tumor vasculature. While nanoparticles are …
through the curves and branches of healthy or tumor vasculature. While nanoparticles are …
Multiscale perspectives of virus entry via endocytosis
E Barrow, AV Nicola, J Liu - Virology journal, 2013 - Springer
Most viruses take advantage of endocytic pathways to gain entry into host cells and initiate
infections. Understanding of virus entry via endocytosis is critically important for the design …
infections. Understanding of virus entry via endocytosis is critically important for the design …
Non-affinity factors modulating vascular targeting of nano-and microcarriers
Particles capable of homing and adhering to specific vascular biomarkers have potential as
fundamental tools in drug delivery for mediation of a wide variety of pathologies, including …
fundamental tools in drug delivery for mediation of a wide variety of pathologies, including …
Multiscale systems biology and physics of thrombosis under flow
MH Flamm, SL Diamond - Annals of biomedical engineering, 2012 - Springer
Blood clotting under hemodynamic conditions involves numerous multiscale interactions
from the molecular scale to macroscopic vessel and systemic circulation scales …
from the molecular scale to macroscopic vessel and systemic circulation scales …
The influence of flow, shear stress and adhesion molecule targeting on gold nanoparticle uptake in human endothelial cells
The uptake of nanoparticles by endothelial cells is dependent on shear stress adaptation
and flow exposure conditions. Adaptation of primary human umbilical vein endothelial cells …
and flow exposure conditions. Adaptation of primary human umbilical vein endothelial cells …