Vascular calcification is highly associated with cardiovascular disease mortality, particularly
in high-risk patients with diabetes and chronic kidney diseases (CKD). In blood vessels …

Premature aging is a process associated with a progressive accumulation of deleterious
changes over time, an impairment of physiologic functions, and an increase in the risk of …

Results Nondialysis patients were older than the predialysis group (82 versus 67 years; P<
0.001) but had similar eGFR at the first clinic visit (16 ml/min per 1.73 m 2; P= 0.92). Of the …

Hyperphosphatemia in chronic kidney disease (CKD) patients is a potentially life altering
condition that can lead to cardiovascular calcification, metabolic bone disease (renal …

At the early stage of chronic kidney disease (CKD), the systemic mineral metabolism and
bone composition start to change. This alteration is known as chronic kidney disease …

Chronic kidney disease is a devastating condition resulting from irreversible loss of nephron
numbers and function and leading to end-stage renal disease and mineral disorders …

In recent years, the imbalance in phosphate homeostasis in patients with end-stage renal
disease (ESRD) has been the subject of much research. It appears that, while …

Despite 10 years of post‐marketing safety monitoring of the phosphate binder lanthanum
carbonate, concerns about aluminium‐like accumulation and toxicity persist. Here, we …

Non-systemic drugs act within the intestinal lumen without reaching the systemic circulation.
The first generation included polymeric resins that sequester phosphate ions, potassium …

Background: Chronic kidney disease (CKD) affects approximately 15% of adults in the USA.
As CKD progresses, urinary phosphate excretion decreases and results in phosphate …