Keratoconus: an inflammatory disorder?

V Galvis, T Sherwin, A Tello, J Merayo, R Barrera… - Eye, 2015 - nature.com
Keratoconus has been classically defined as a progressive, non-inflammatory condition,
which produces a thinning and steepening of the cornea. Its pathophysiological …

Keratoconus

RB Singh, S Koh, N Sharma, FA Woreta… - Nature Reviews …, 2024 - nature.com
Keratoconus is a progressive eye disorder primarily affecting individuals in adolescence and
early adulthood. The ectatic changes in the cornea cause thinning and cone-like steepening …

Genetics vs chronic corneal mechanical trauma in the etiology of keratoconus

YS Rabinowitz, V Galvis, A Tello, D Rueda… - Experimental eye …, 2021 - Elsevier
Both genetic and environmental factors have been considered to play a role in the etiology
keratoconus. Eye rubbing, and more recently eye compression due to sleeping position …

Keratoconus diagnosis and treatment: recent advances and future directions

AD Bui, A Truong, ND Pasricha… - Clinical …, 2023 - Taylor & Francis
Keratoconus is a disorder characterized by progressive corneal thinning and steepening
that may result in significant visual impairment secondary to high astigmatism, corneal …

Pediatric keratoconus-Current perspectives and clinical challenges

V Anitha, M Vanathi, A Raghavan… - Indian Journal of …, 2021 - journals.lww.com
Keratoconus is an ectatic corneal disease characterized by progressive stromal thinning,
irregular astigmatism, and defective vision. It can be unilateral or bilateral with asymmetric …

Oxidative and antioxidative stress markers in keratoconus: a systematic review and meta‐analysis

V Navel, J Malecaze, B Pereira, JS Baker… - Acta …, 2021 - Wiley Online Library
Purpose To conduct a systematic review and meta‐analysis on the levels of oxidative stress
markers and antioxidants in keratoconus compared to healthy subject. Method The PubMed …

Systemic associations with keratoconus

P Unni, HJ Lee - Life, 2023 - mdpi.com
Keratoconus is a disease of the cornea that results in progressive steepening and thinning
of the cornea and subsequent vision loss. It nearly always presents as a bilateral disease …

The genetics of keratoconus

HYP Chang, J Chodosh - Seminars in ophthalmology, 2013 - Taylor & Francis
Keratoconus is a bilateral, non-inflammatory corneal ectasia characterized by progressive
conical thinning and protrusion of the cornea. Its etiology has long been believed to be …

Association of Lysyl oxidase (LOX) Polymorphisms with the Risk of Keratoconus in an Iranian Population

F Hasanian-Langroudi, R Saravani… - Ophthalmic …, 2015 - Taylor & Francis
Background: Keratoconus is a connective tissue-related eye disease with unknown etiology
that causes the loss of visual acuity. Lysyl oxidase (LOX) is an amine oxidase that catalyzes …

Elastin turnover in ocular diseases: A special focus on age-related macular degeneration

S Navneet, B Rohrer - Experimental eye research, 2022 - Elsevier
The extracellular matrix (ECM) and its turnover play a crucial role in the pathogenesis of
several inflammatory diseases, including age-related macular degeneration (AMD). Elastin …