Peptides are molecules of paramount importance in the fields of health care and nutrition.
Several technologies for their production are now available, among which chemical and …

Malaria is the most important insect-transmitted human disease, but progress in its control
has been slow, especially in Africa where approximately 90% of the infections occur …

Immunization is one of the great advances in public health. Figure 0.1 shows a camel with a
solar-powered refrigerator on his back carrying vaccines across a hot desert to the far …

Effective, safe antimalarial vaccines have proved elusive. The synthetic polypeptide SPf66
vaccine is based on pre-erythrocytic and asexual blood-stage proteins of Plasmodium …

Preclinical and clinical studies have established the safety and immunogenicity of the
chemically synthesised SPf66 malaria vaccine. The present study is a phase III randomised …

SPf66 malaria vaccine is a synthetic protein with aminoacid sequences derived from pre-
erythrocytic and asexual blood-stage proteins of Plasmodium falciparum. SPf66 was found …

We investigated the prevalence and magnitude of naturally acquired humoral immune
response to the major merozoite surface protein (MSP-1) in a malaria-endemic population in …

Dedicated to the memory of Professors Henry G. Kunkel and Bruce Merrifield (Rockefeller
University, New York), who introduced us to the fascinating worlds of immunology and …

Montanide® ISA 720 is an experimental adjuvant, formulated as water-in-oil emulsions, that
induces high antibody titers in several animal species. It has been used in human vaccine …

Background A malaria vaccine is badly needed. SPf66 was one of the earliest vaccines
developed. It is a synthetic peptide vaccine containing antigens from the blood stages of …