Chirality can be exploited to gain insight into enantioselective fate processes that may
otherwise remain undetected because only biological, but not physical and chemical …

Seventy eight out of the 209 possible polychlorinated biphenyl (PCB) congeners are chiral,
19 of which exist under ambient conditions as stable rotational isomers that are non …

Exposure to polychlorinated biphenyls (PCBs) and their hydroxylated metabolites (OH-
PCBs) has been implicated in neurodevelopmental disorders. However, the distribution of …

Polychlorinated biphenyls (PCBs), a group of 209 congeners that differ in the number and
position of chlorines on the biphenyl ring, are anthropogenic chemicals that belong to the …

Background Gestational exposure to polychlorinated biphenyls (PCBs) has been associated
with elevated risk for neurodevelopmental disorders. Placental epigenetics may serve as a …

Epidemiological and laboratory studies link polychlorinated biphenyls and their metabolites
to adverse neurodevelopmental outcomes. Several neurotoxic PCB congeners are chiral …

Recent studies show that, even after being banned for agricultural applications for over 30
years, organochlorine pesticides (OCPs), including hexachlorocyclohexanes (HCHs) and …

Chiral PCB congeners are major components of PCB mixtures and undergo
enantioselective biotransformation to hydroxylated (OH-) PCBs by cytochrome P450 …

To understand the role of hepatic vs extrahepatic metabolism in the disposition of chiral
PCBs, we studied the disposition of 2, 2′, 3, 3′, 6, 6′-hexachlorobiphenyl (PCB 136) and …

Mouse models are powerful tools to study the developmental neurotoxicity of
polychlorinated biphenyls (PCBs); however, studies of the oxidation of chiral PCB …