Zebrafish have several advantages compared to other vertebrate models used in modeling
human diseases, particularly for large-scale genetic mutant and therapeutic compound …

While epigenetic modifications of DNA and histones play main roles in gene transcription
regulation, recently discovered post-transcriptional RNA modifications, known as …

Heart disease is the leading cause of death worldwide. Despite decades of research, most
heart pathologies have limited treatments, and often the only curative approach is heart …

Heart failure causes significant morbidity and mortality worldwide. The understanding of
heart failure pathomechanisms and options for treatment remain incomplete. Zebrafish has …

Cardiovascular disease (CVD) is the leading cause of death in the world, with a high
incidence and a youth-oriented tendency. RNA modification is ubiquitous and indispensable …

Pseudouridine (Ψ) at position 55 in tRNAs plays an important role in their structure and
function. This modification is catalyzed by TruB/Pus4/Cbf5 family of pseudouridine …

Mitochondria are the main site of intracellular synthesis of ATP, which provides energy for
various physiological activities of the cell. Cardiomyocytes have a high density of …

In this report, we investigated the molecular mechanism underlying a deafness-associated
m. 5783C> T mutation that affects the canonical C50-G63 base-pairing of TΨC stem of …

Defects in the posttranscriptional modifications of mitochondrial tRNAs have been linked to
human diseases, but their pathophysiology remains elusive. In this report, we investigated …

Transfer RNAs (tRNAs) harbor the most diverse posttranscriptional modifications. Among
such modifications, those in the anticodon loop, either on nucleosides or base groups …