The microbiome and gut homeostasis

JY Lee, RM Tsolis, AJ Bäumler - Science, 2022 - science.org
Changes in the composition of the gut microbiota are associated with many human
diseases. So far, however, we have failed to define homeostasis or dysbiosis by the …

Microbiota-mediated colonization resistance: mechanisms and regulation

G Caballero-Flores, JM Pickard, G Núñez - Nature Reviews …, 2023 - nature.com
A dense and diverse microbial community inhabits the gut and many epithelial surfaces.
Referred to as the microbiota, it co-evolved with the host and is beneficial for many host …

[HTML][HTML] The role of NADPH oxidases in infectious and inflammatory diseases

JP Taylor, MT Hubert - Redox biology, 2021 - Elsevier
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX) are enzymes that
generate superoxide or hydrogen peroxide from molecular oxygen utilizing NADPH as an …

Reactive oxygen species: not omnipresent but important in many locations

M Herb, A Gluschko, M Schramm - Frontiers in cell and …, 2021 - frontiersin.org
Reactive oxygen species (ROS), such as the superoxide anion or hydrogen peroxide, have
been established over decades of research as, on the one hand, important and versatile …

[HTML][HTML] Host/microbiota interactions in health and diseases—Time for mucosal microbiology!

N Daniel, E Lécuyer, B Chassaing - Mucosal Immunology, 2021 - Elsevier
During the last 20 years, a new field of research delineating the importance of the microbiota
in health and diseases has emerged. Inappropriate host-microbiota interactions have been …

Sialic acid plays a pivotal role in licensing Citrobacter rodentium's transition from the intestinal lumen to a mucosal adherent niche

Q Liang, C Ma, SM Crowley… - Proceedings of the …, 2023 - National Acad Sciences
Enteric bacterial pathogens pose significant threats to human health; however, the
mechanisms by which they infect the mammalian gut in the face of daunting host defenses …

Leaf microbiome dysbiosis triggered by T2SS-dependent enzyme secretion from opportunistic Xanthomonas pathogens

S Pfeilmeier, A Werz, M Ote, M Bortfeld-Miller… - Nature …, 2024 - nature.com
In healthy plants, the innate immune system contributes to maintenance of microbiota
homoeostasis, while disease can be associated with microbiome perturbation or dysbiosis …

Commensal lifestyle regulated by a negative feedback loop between Arabidopsis ROS and the bacterial T2SS

F Entila, X Han, A Mine, P Schulze-Lefert… - Nature …, 2024 - nature.com
Despite the plant health-promoting effects of plant microbiota, these assemblages also
comprise potentially detrimental microbes. How plant immunity controls its microbiota to …

Colonocyte-derived lactate promotes E. coli fitness in the context of inflammation-associated gut microbiota dysbiosis

SJ Taylor, MG Winter, CC Gillis, LA Silva, AL Dobbins… - Microbiome, 2022 - Springer
Background Intestinal inflammation disrupts the microbiota composition leading to an
expansion of Enterobacteriaceae family members (dysbiosis). Associated with this shift in …

Structural basis for peroxidase encapsulation inside the encapsulin from the Gram-negative pathogen Klebsiella pneumoniae

JA Jones, MP Andreas, TW Giessen - Nature Communications, 2024 - nature.com
Encapsulins are self-assembling protein nanocompartments capable of selectively
encapsulating dedicated cargo proteins, including enzymes involved in iron storage, sulfur …