Repositioning the role of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on the TRAIL to the development of diabetes mellitus: An update of …

C Koliaki, N Katsilambros - International journal of molecular sciences, 2022 - mdpi.com
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the
TNF protein superfamily, represents a multifaceted cytokine with unique biological features …

On the TRAIL of obesity and diabetes

HH Harith, MJ Morris, MM Kavurma - Trends in Endocrinology & Metabolism, 2013 - cell.com
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) has been extensively
studied for its preferential ability to induce apoptosis of cancer cells. Beyond the cytotoxic …

TNF-related apoptosis-inducing ligand (TRAIL) protects against diabetes and atherosclerosis in Apoe −/− mice

BA Di Bartolo, J Chan, MR Bennett, S Cartland, S Bao… - Diabetologia, 2011 - Springer
Aims/hypothesis TNF-related apoptosis-inducing ligand (TRAIL) is implicated in the
regulation of diabetes and is reduced in patients with cardiovascular disease. Although …

[HTML][HTML] Immunomodulatory Functions of TNF-Related Apoptosis-Inducing Ligand in Type 1 Diabetes

M Fogarasi, S Dima - Cells, 2024 - mdpi.com
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the
TNF protein superfamily and was initially identified as a protein capable of inducing …

TRAIL, OPG, and TWEAK in kidney disease: biomarkers or therapeutic targets?

S Bernardi, R Voltan, E Rimondi, E Melloni… - Clinical …, 2019 - portlandpress.com
Ligands and receptors of the tumor necrosis factor (TNF) superfamily regulate immune
responses and homeostatic functions with potential diagnostic and therapeutic implications …

[HTML][HTML] TNF-related apoptosis-inducing ligand (TRAIL) as the potential therapeutic target in hematological malignancies

A Naimi, AA Movassaghpour, MF Hagh… - Biomedicine & …, 2018 - Elsevier
Despite numerous attempts to find the treatment strategies that can selectively target the
cancer cells, cancer still remains a major public health problem. Conventional cancer …

Therapeutic potential of VIP vs PACAP in diabetes

AD Sanlioglu, B Karacay, MK Balci… - Journal of …, 2012 - jme.bioscientifica.com
Type 2 diabetes (T2D) is characterized by chronic insulin resistance and a progressive
decline in beta-cell function. Although rigorous glucose control can reduce morbidity and …

Targeting the Apo2L/TRAIL system for the therapy of autoimmune diseases and cancer

L Martinez-Lostao, I Marzo, A Anel, J Naval - Biochemical pharmacology, 2012 - Elsevier
Apo 2 ligand/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL),
is a member of the TNF family of cytokines, which can induce apoptotic cell death in cells …

Treatment with recombinant tumor necrosis factor–related apoptosis-inducing ligand alleviates the severity of streptozotocin-induced diabetes

G Zauli, B Toffoli, MG di Iasio, C Celeghini, B Fabris… - Diabetes, 2010 - Am Diabetes Assoc
OBJECTIVE To evaluate the potential therapeutic effect of recombinant human tumor
necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) treatment in a model of type …

Gene and cell therapy of human genetic diseases: Recent advances and future directions

B Cetin, F Erendor, YE Eksi… - Journal of Cellular …, 2024 - Wiley Online Library
Disruptions in normal development and the emergence of health conditions often result from
the malfunction of vital genes in the human body. Decades of scientific research have …