Heterogeneity is a key feature of all psychiatric disorders that manifests on many levels,
including symptoms, disease course, and biological underpinnings. These form a …

For every disorder, there is a set of established findings and accepted constructs upon which
further understanding is built. The concept of schizophrenia as a disease entity has been …

Patients with mental disorders show many biological abnormalities which distinguish them
from normal volunteers; however, few of these have led to tests with clinical utility. Several …

Importance A major public health concern associated with schizophrenia and psychotic
disorders is the long-term disability that involves impaired cognition, lack of social support …

Objective: A high incidence of psychotic disorders has been reported in immigrant ethnic
groups in Western Europe. Some studies suggest that ethnic density may influence the …

It has recently been suggested that the diagnostic criteria of schizophrenia should include
specific reference to cognitive impairments characterizing the disorder. Arguments in …

Cognitive tasks and concepts are used increasingly in schizophrenia science and treatment.
Recent meta-analyses show that across a spectrum of research domains only cognitive …

Phenotypic variability and likely extensive genetic heterogeneity have been confounding the
search for the causes of schizophrenia since the inception of the diagnostic category. The …

Background: Neurological soft signs (NSS) are hypothesized as candidate endophenotypes
for schizophrenia, but their prevalence and relations with clinical and demographic data are …

Endophenotypes for psychopathology have been conceived as latent, unobserved, but
measureable manifestations of phenomena that causally connect genetic liability to clinical …