The dynamic regulation of chromatin accessibility is one of the prominent characteristics of
eukaryotic genome. The inaccessible regions are mainly located in heterochromatin, which …

The activation of the zygotic genome constitutes an essential process during early
embryogenesis that determines the overall progression of embryonic development. Zygotic …

Disruption of neocortical circuitry and architecture in humans causes numerous
neurodevelopmental disorders. Neocortical cytoarchitecture is orchestrated by various …

SATB2-associated syndrome (SAS) is a multisystem disorder in which all affected
individuals have developmental delay/intellectual disability that can range from mild to …

The human brain contains multiple cell types that are spatially organized into functionally
distinct regions. The proper development of the brain requires complex gene regulation …

Neuronal activity, including sensory-evoked and spontaneous firing, regulates the
expression of a subset of genes known as activity-dependent genes. A key issue in this …

The three-dimensional organization of the genome plays a central role in the regulation of
cellular functions, particularly in the human brain. This review explores the intricacies of …

Even though epigenetic factors contribute to oncogenesis, most human cancer models still
assume that disease originates from driver DNA mutations. Thus, it is still unclear if non …