Particular working conditions and/or organization of working time may cause important sleep
disturbances that have been proposed to be predictive of cognitive decline. In this regard …

INTRODUCTION At the Alzheimer's Association's APOE and Immunity virtual conference,
held in October 2021, leading neuroscience experts shared recent research advances on …

Background The ε4 allele of the apolipoprotein E gene (APOE4) plays a role in
neurodegeneration and in cardiovascular disease, but findings on its association with …

We examined associations between cognition and mortality and how these relationships
vary by race and Apolipoprotein E (APOE) genotype, in a longitudinal study of 2346 middle …

Background Clinical trials in older adults are increasingly focused on functional outcomes,
and the composite outcome of dementia, disability, and death is gaining pivotal importance …

BACKGROUND: APOE is a known genetic contributor to cardiovascular disease, but the
differential role APOE alleles play in subclinical atherosclerosis remains unclear …

Introduction At least one-third of the identified risk alleles from Genome-Wide Association
Studies (GWAS) of Alzheimer's disease (AD) are involved in lipid metabolism, lipid transport …

The term “Primary age-related tauopathy”(PART) was coined in 2014 to describe the
common neuropathological observation of neurofibrillary tangles without associated beta …

Background: Dementia, vascular disease, and cancer increase with age, enabling complex
comorbid interactions. Understanding vascular and cancer contributions to dementia risk …

This study aimed to evaluate whether genetic polymorphism is associated with an increased
risk of infection, specifically post-stroke aspiration pneumonia. Blood samples were obtained …