Searching for drugs for Chagas disease, leishmaniasis and schistosomiasis: a review
Chagas disease, leishmaniasis and schistosomiasis are neglected diseases (NDs) and are
a considerable global challenge. Despite the huge number of people infected, NDs do not …
a considerable global challenge. Despite the huge number of people infected, NDs do not …
Medicinal chemistry of antischistosomal drugs: Praziquantel and oxamniquine
VBR da Silva, BRKL Campos, JF de Oliveira… - Bioorganic & medicinal …, 2017 - Elsevier
Neglected tropical diseases (NTDs) are a group of diseases that, besides prevailing in
poverty conditions, contribute to the maintenance of social inequality, being a strong barrier …
poverty conditions, contribute to the maintenance of social inequality, being a strong barrier …
A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motility
MJ Smout, AC Kotze, JS McCarthy… - PLoS neglected tropical …, 2010 - journals.plos.org
Background Helminth parasites cause untold morbidity and mortality to billions of people
and livestock. Anthelmintic drugs are available but resistance is a problem in livestock …
and livestock. Anthelmintic drugs are available but resistance is a problem in livestock …
Antischistosomal agents: state of art and perspectives
EM Lago, RP Xavier, TR Teixeira, LM Silva… - Future Medicinal …, 2018 - Taylor & Francis
Praziquantel has remained the drug of choice for schistosomiasis chemotherapy for almost
40 years. The pressing need to develop a new antischistosomal drug may necessitate …
40 years. The pressing need to develop a new antischistosomal drug may necessitate …
Natural products with antischistosomal activity
J de Moraes - Future Medicinal Chemistry, 2015 - Taylor & Francis
In recent years, natural product groups have been gaining prominence as possible sources
of new drugs for schistosomiasis. This review attempts to update the antischistosomal …
of new drugs for schistosomiasis. This review attempts to update the antischistosomal …
Drug repurposing for schistosomiasis: combinations of drugs or biomolecules
MJ Gouveia, PJ Brindley, F Gärtner, JMC Costa… - Pharmaceuticals, 2018 - mdpi.com
Schistosomiasis is a major neglected tropical disease. Control of schistosomiasis currently
relies on a single drug, praziquantel, and despite its efficacy against the all schistosome …
relies on a single drug, praziquantel, and despite its efficacy against the all schistosome …
The mechanism of action of praziquantel: can new drugs exploit similar mechanisms?
CM Thomas, DJ Timson - Current Medicinal Chemistry, 2020 - ingentaconnect.com
Praziquantel (PZQ) is the drug of choice for treating infection with worms from the genus
Schistosoma. The drug is effective, cheap and has few side effects. However, despite its use …
Schistosoma. The drug is effective, cheap and has few side effects. However, despite its use …
Present-day anthelmintics and perspectives on future new targets
In absence of vaccines for the majority of helminths, chemotherapy is still the mainstay for
controlling human helminthiases. However, a limited number of drugs are available in the …
controlling human helminthiases. However, a limited number of drugs are available in the …
Gene suppression in schistosomes using RNAi
AA Da'dara, PJ Skelly - Parasite Genomics Protocols, 2015 - Springer
Schistosomiasis is a neglected tropical disease responsible for the death of more than
300,000 people every year. The disease is caused by intravascular parasitic platyhelminths …
300,000 people every year. The disease is caused by intravascular parasitic platyhelminths …
Antiparasitic peptides
J Pretzel, F Mohring, S Rahlfs, K Becker - Yellow Biotechnology I: Insect …, 2013 - Springer
<? xm-replace_text {Heading}?> Abstract The most important parasitic diseases, malaria,
leishmaniasis, trypanosomiasis, and schistosomiasis, are a great burden to mankind …
leishmaniasis, trypanosomiasis, and schistosomiasis, are a great burden to mankind …