Targeting strategies for bone diseases: signaling pathways and clinical studies
H Xu, W Wang, X Liu, W Huang, C Zhu, Y Xu… - … and Targeted Therapy, 2023 - nature.com
Since the proposal of Paul Ehrlich's magic bullet concept over 100 years ago, tremendous
advances have occurred in targeted therapy. From the initial selective antibody, antitoxin to …
advances have occurred in targeted therapy. From the initial selective antibody, antitoxin to …
miRNAs as therapeutic targets in inflammatory disease
Q Lu, R Wu, M Zhao, A Garcia-Gomez… - Trends in pharmacological …, 2019 - cell.com
In the past decade, we have witnessed considerable developments in understanding the
roles and functions of miRNAs. In parallel, the identification of alterations in miRNA …
roles and functions of miRNAs. In parallel, the identification of alterations in miRNA …
CircERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axis
L Xie, W Huang, Z Fang, F Ding, F Zou, X Ma… - Cell Death & …, 2019 - nature.com
The molecular mechanism of intervertebral disc degeneration (IVDD) remains unclear. This
study aimed to investigate the role of circular RNAs (circRNAs) in the pathogenesis of IVDD …
study aimed to investigate the role of circular RNAs (circRNAs) in the pathogenesis of IVDD …
Osteoclast-mediated bone resorption is controlled by a compensatory network of secreted and membrane-tethered metalloproteinases
Osteoclasts actively remodel both the mineral and proteinaceous components of bone
during normal growth and development as well as pathologic states ranging from …
during normal growth and development as well as pathologic states ranging from …
The role of microRNAs in bone development
AP Hensley, A McAlinden - Bone, 2021 - Elsevier
Epigenetic regulation is critical for proper bone development. Evidence from a large body of
published literature informs us that microRNAs (miRNAs) are important epigenetic factors …
published literature informs us that microRNAs (miRNAs) are important epigenetic factors …
Cytokine-mediated immunomodulation of osteoclastogenesis
Cytokines are an important set of proteins regulating bone homeostasis. In inflammation
induced bone resorption, cytokines, such as RANKL, TNF-α, M-CSF, are indispensable for …
induced bone resorption, cytokines, such as RANKL, TNF-α, M-CSF, are indispensable for …
[HTML][HTML] Circulating miR-338 cluster activities on osteoblast differentiation: potential diagnostic and therapeutic targets for postmenopausal osteoporosis
MicroRNAs (miRNAs) are the most abundant RNA species found in serum, and recently,
several miRNAs have been found to be associated with osteoporosis. However, the …
several miRNAs have been found to be associated with osteoporosis. However, the …
Exploring the feasibility of circulating miRNAs as diagnostic and prognostic biomarkers in osteoarthritis: Challenges and opportunities
Osteoarthritis (OA) is a prevalent degenerative joint disease characterized by progressive
cartilage degradation and joint inflammation. As the most common aging-related joint …
cartilage degradation and joint inflammation. As the most common aging-related joint …
Mmu-miR-185 depletion promotes osteogenic differentiation and suppresses bone loss in osteoporosis through the Bgn-mediated BMP/Smad pathway
Q Cui, J Xing, M Yu, Y Wang, J Xu, Y Gu, X Nan… - Cell death & …, 2019 - nature.com
MicroRNAs (miRs) play an essential role in the regulation of bone formation and
homeostasis. miR-185 has been reported to negatively regulate osteogenesis in vitro …
homeostasis. miR-185 has been reported to negatively regulate osteogenesis in vitro …
Aberrant activation of immune and non-immune cells contributes to joint inflammation and bone degradation in rheumatoid arthritis
KS Nandakumar, Q Fang, I Wingbro Ågren… - International Journal of …, 2023 - mdpi.com
Abnormal activation of multiple immune and non-immune cells and proinflammatory factors
mediate the development of joint inflammation in genetically susceptible individuals …
mediate the development of joint inflammation in genetically susceptible individuals …