The availability of in vitro tools that are constructed on the basis of a detailed knowledge of
key aspects of gastrointestinal (GI) physiology and their impact on formulation performance …

Objectives Co-ingestion of oral dosage forms with meals can cause substantial changes in
bioavailability relative to the fasted state. Food-mediated effects on bioavailability can have …

Amorphous solid dispersions (ASDs) are one of the frontier strategies to improve solubility
and dissolution rate of poorly soluble drugs and hence tackling the growing challenges in …

Before being absorbed in the small intestine and/or colon, orally administered drugs
inevitably need to pass through the stomach. Hence, it seems reasonable that the residence …

Food effects on oral drug bioavailability can have significant impact on the provision of safe
and reliable oral pharmacotherapy. A mechanistic understanding of the events that …

Concomitant food intake can diminish oral absorption of drugs with limited permeability and
an absorption window in the proximal intestine, due to viscosity-mediated decrease in …

Supercritical fluid extrusion (SCFX) processing was used to develop milk protein-based
orally self-disintegrating puffs enriched with fruit and dairy by-products, designed specifically …

Drug product performance testing is an important part of quality-by-design approaches, but
this process often lacks the underlying mechanistic understanding of the complex …

Purpose The purpose of the present study was to investigate the effect of food viscosity on
the dissolution rate of a drug. There are two types of viscosity, macroviscosity and …

Viscosity, influenced by medium composition, will affect the hydrodynamics of a dissolution
system. Dissolution simulation methods are valuable tools to explore mechanistic …