Doxorubicin (DOX), as a kind of chemotherapy agent with remarkable therapeutic effect, can
be used to treat diverse malignant tumors clinically. Dose-dependent cardiotoxicity is the …

Cardiovascular diseases have become a major clinical burden globally. Heart failure is one
of the diseases that commonly emanates from progressive uncontrolled hypertension. This …

Simple Summary Anthracycline-induced cardiotoxicity (AIC) poses a significant clinical
challenge in the management of cancer patients. Thus, the development of effective …

We aimed to probe the functions and possible mechanisms of empagliflozin in doxorubicin
(Dox)-caused cardiotoxicity. First, a cardiotoxicity rat model was built by continuously …

Sepsis is a life-threatening situation that ultimately affects cardiac function, leading to
cardiomyopathy and myocardial injury as a result of uncontrolled response to infection. Till …

Background: Doxorubicin is a widely used agent in the treatment of cancer, but the
cardiotoxicity associated with this drug limits its potential for use. The cardioprotective effects …

Objective: Oxidative stress and hypoxia play an important role in the pathogenesis of various
cardiovascular diseases. We aimed to evaluate the effectiveness of sacubitril/valsartan (S/V) …

Anticancer agents can cause various side effects, including tissue damages/inflammatory
reactions. Drug-responsive biomarkers are essential for evaluating drug toxicity in disease …

Doxorubicin (DOX), which is widely used for the treatment of cancer, induces
cardiomyopathy associated with NADPH oxidase-derived reactive oxygen species …

Objectives Drug-induced cardiac injury is a potentially preventable cause of heart failure.
Cisplatin (CIS) is a widely used chemotherapeutic agent complicated with cardiotoxicity that …