To improve discovery of drugs for difficult targets, the opportunities of chemical space
beyond the rule of 5 (bRo5) were examined by retrospective analysis of a comprehensive …

As a bone scaffold, meeting all basic requirements besides dealing with other bone-related
issues—bone cancer and accelerated regeneration—is not expected from traditional …

Nuclear receptors are classically defined as ligand-activated transcription factors that
regulate key functions in reproduction, development, and physiology. Humans have 48 …

mRNA display is a powerful biological display platform for the directed evolution of proteins
and peptides. mRNA display libraries covalently link the displayed peptide or protein …

The extracellular signal-regulated kinases (ERKs) comprise a particular branch of the
mitogen-activated protein kinase cascades (MAPK) that transmits extracellular signals into …

GPCRs are the most successful pharmaceutical targets in history. Nevertheless, the
pharmacology of many GPCRs remains inaccessible as their endogenous or exogenous …

Highlights•Economic, scientific and strategic challenges of the pharmaceutical industry are
analyzed.•New approaches to increase the output of innovative medicine are …

Colorectal cancer (CRC), ranking as the third most common cancer globally, is associated
with a high death rate. The colon, also known as the large intestine, is the site where …

Presented here are several data sets that gather information collected from the labels of the
FDA approved drugs: their molecular structures and those of the described active …

The discovery and development of first-in-class (FIC) drugs are becoming increasingly
important due to increasing reimbursement pressure and personalized medication. To …