Alcohol use disorders and ADHD

M Luderer, JAR Quiroga, SV Faraone… - Neuroscience & …, 2021 - Elsevier
Despite a growing literature on the complex bidirectional relationship of ADHD and
substance use, reviews specifically focusing on alcohol are scarce. ADHD and AUD show a …

ADHD co-morbidities: A review of implication of gene× environment effects with dopamine-related genes

M Kanarik, O Grimm, NR Mota, A Reif… - … & Biobehavioral Reviews, 2022 - Elsevier
ADHD is a major burden in adulthood, where co-morbid conditions such as depression,
substance use disorder and obesity often dominate the clinical picture. ADHD has …

Structural insights into adhesion GPCR ADGRL3 activation and Gq, Gs, Gi, and G12 coupling

Y Qian, Z Ma, C Liu, X Li, X Zhu, N Wang, Z Xu, R Xia… - Molecular Cell, 2022 - cell.com
Adhesion G-protein-coupled receptors (aGPCRs) play key roles in a diversity of
physiologies. A hallmark of aGPCR activation is the removal of the inhibitory GAIN domain …

G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

S Mathiasen, T Palmisano, NA Perry… - Nature chemical …, 2020 - nature.com
The adhesion G-protein-coupled receptor (GPCR) latrophilin 3 (ADGRL3) has been
associated with increased risk of attention deficit hyperactivity disorder (ADHD) and …

Structure, function and drug discovery of GPCR signaling

L Cheng, F Xia, Z Li, C Shen, Z Yang, H Hou… - Molecular …, 2023 - Springer
G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide
array of physiological processes and responses, such as sensory perception (eg, vision …

Latrophilins: a neuro-centric view of an evolutionary conserved adhesion G protein-coupled receptor subfamily

AL Moreno-Salinas, M Avila-Zozaya… - Frontiers in …, 2019 - frontiersin.org
The adhesion G protein-coupled receptors latrophilins have been in the limelight for more
than 20 years since their discovery as calcium-independent receptors for α-latrotoxin, a …

Machine Learning Prediction of ADHD Severity: Association and Linkage to ADGRL3, DRD4, and SNAP25

ML Cervantes-Henríquez… - Journal of Attention …, 2022 - journals.sagepub.com
Objective: To investigate whether single nucleotide polymorphisms (SNPs) in the ADGRL3,
DRD4, and SNAP25 genes are associated with and predict ADHD severity in families from a …

[HTML][HTML] Machine learning based psychology: Advocating for a data-driven approach

JI Vélez - International Journal of Psychological Research, 2021 - scielo.org.co
Since its beginnings, Psychology has been prone to both data generation and
understanding of human behavior through data analysis. Back in 1879, Dr. Wilheim Wundt …

Knockout of latrophilin-3 in Sprague-Dawley rats causes hyperactivity, hyper-reactivity, under-response to amphetamine, and disrupted dopamine markers

SL Regan, JR Hufgard, EM Pitzer, C Sugimoto… - Neurobiology of …, 2019 - Elsevier
Attention deficit hyperactivity disorder is a pervasive developmental disorder characterized
by inattention, impulsivity, and hyperactivity and is 75–90% heritable. Latrophilin-3 (LPHN3; …

Novel non-stimulants rescue hyperactive phenotype in an adgrl3.1 mutant zebrafish model of ADHD

HS Sveinsdóttir, C Christensen… - …, 2023 - nature.com
ADHD is a highly prevalent neurodevelopmental disorder. The first-line therapeutic for
ADHD, methylphenidate, can cause serious side effects including weight loss, insomnia …