Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in
membrane remodelling, has a critical role in endocytic membrane fission events. The use of …

We discuss here the variety of approaches that have been taken to inhibit different forms of
endocytosis. Typically, both non-specific and specific chemical inhibitors of endocytosis are …

While the dynamin GTPase Drp1 plays a critical role during mitochondrial fission,
mechanisms controlling its recruitment to fission sites are unclear. A current assumption is …

ABSTRACT A key event in the evolution of eukaryotic cells was the engulfment of an aerobic
bacterium by a larger anaerobic archaebacterium, leading to a close relationship between …

Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …

Intensive research in the field of cancer biology has revealed unique methods of
communication between cells through extracellular vesicles called exosomes. Exosomes …

Dynamin GTPase activity increases when it oligomerizes either into helices in the presence
of lipid templates or into rings in the presence of SH3 domain proteins. Dynasore is a …

Endocytosis includes a number of processes by which cells internalize segments of their
plasma membrane, enclosing a wide variety of material from outside the cell. Endocytosis …

An essential property of the plasma membrane of mammalian cells is its plasticity, which is
required for sensing and transmitting of signals, and for accommodating the tensional …