The deacetylase sirtuin 1 (Sirt1), activated by calorie restriction and fasting, exerts several
complementary effects on cellular function that are favourable to healthspan; it is often …

Mitochondria play a wide diversity of roles in cell physiology and have a key functional
implication in cell bioenergetics and biology of free radicals. As the main cellular source of …

Ischemia/reperfusion (I/R) injury is the central cause of global death in cardiovascular
diseases, which is characterized by disorders such as angina, stroke, and peripheral …

Disruption of circadian oscillations has a wide-ranging impact on health, with the potential to
induce the development of clock-related diseases. Small-molecule modulators of the …

Abstract Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide–dependent deacetylase
that modifies gene expression through histone deacetylation. It also deacetylates …

Arsenic, a widespread environmental poison, can cause significant liver damage upon
exposure. Mitochondria are the most sensitive organelles to external factors. Dysfunctional …

The use of anti-oxidants could thus prove an effective medication to prevent or facilitate
recovery from oxidative stress-induced sensorineural hearing loss (SNHL). One promising …

Abnormal NAD+ signaling has been implicated in axonal degeneration in diabetic
peripheral neuropathy (DPN). We hypothesized that supplementing NAD+ precursors could …

Background Cellular damage gradually accumulates with aging, promoting a time-
dependent functional decline of the brain. Microglia play an essential regulatory role in …

Natural compounds from diverse sources, including botanicals and commonly consumed
foods and beverages, exert beneficial health effects via mechanisms that impact the …