Thrombus formation is increased under conditions of hypoxia in animal models of
thrombosis and in human populations, but current therapies for thrombosis do not directly …

Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by
widespread intravascular activation of coagulation that can be caused by infectious insults …

Ischemia and reperfusion–elicited tissue injury contributes to morbidity and mortality in a
wide range of pathologies, including myocardial infarction, ischemic stroke, acute kidney …

Liver injury, characterized predominantly by elevated aspartate aminotransferase and
alanine aminotransferase, is a common feature of coronavirus disease 2019 (COVID‐19) …

Ischemia–reperfusion–induced lung injury is characterized by nonspecific alveolar damage,
lung edema, and hypoxemia occurring within 72 hours after lung transplantation. The most …

In 1856 Virchow proposed a triad of causes for venous thrombosis, postulating that stasis,
changes in the vessel wall or changes in the blood could lead to thrombosis. We now know …

Ischemia‐reperfusion (IR) injury is directly related to the formation of reactive oxygen
species (ROS), endothelial cell injury, increased vascular permeability, and the activation of …

Exposure of rats to hypoxia (7% O 2) markedly increased the level of heme oxygenase-1
(HO-1) mRNA in several tissues. Accumulation of HO-1 transcripts was also observed after …

Background—Multiple studies have individually documented cardiac dysfunction and
biochemical evidence of cardiac injury after endurance sports; however, convincing …

Hypoxia in vivo is associated with constriction of the distal vasculature in the lung. Uniquely
situated at the interface between blood and the vessel wall proper, the vascular endothelium …