Protamines are the major nuclear sperm proteins. The human sperm nucleus contains two
types of protamine: protamine 1 (P1) encoded by a single-copy gene and the family of …

Purpose Advancing maternal and paternal age leads to a decrease in fertility, and hence,
many infertile couples opt for assisted reproductive technologies [ART] to achieve biological …

Male infertility is a complex condition with a strong genetic and epigenetic background. This
review discusses the importance of genetic and epigenetic factors in the pathophysiology of …

DNA damage is a common feature of human spermatozoa with purported links to poor rates
of conception, impaired embryonic development, an increased incidence of miscarriage and …

Aim: Sperm chromatin/DNA integrity is essential for the accurate transmission of paternal
genetic information, and normal sperm chromatin structure is important for sperm fertilizing …

The exchange of histones with protamines in sperm DNA results in sperm chromatin
compaction and protection. Variations in sperm protamine expression are associated with …

Infertility is a complex disorder with multiple genetic and environmental causes. Although
some specific mutations have been identified, other factors responsible for sperm defects …

OBJECTIVE: To evaluate whether aberrant sperm P1/P2 ratios are predictive of abnormal
fertilizing ability and are related to in vitro fertilization (IVF) outcome. DESIGN: Prospective …

The aim of this study was to evaluate the effect of sperm DNA damage and protamine
deficiency on fertilization and embryo development post-intracytoplasmic sperm injection …

Histone-to-protamine transition is an essential step in the generation of fully functional
spermatozoa in various mammalian species. In human and mouse, one of the two protamine …