Malaria eradication within a generation: ambitious, achievable, and necessary

RGA Feachem, I Chen, O Akbari, A Bertozzi-Villa… - The Lancet, 2019 - thelancet.com
Executive summary 50 years after a noble but flawed attempt to eradicate malaria in the mid-
20th century, the global malaria community is once again seriously considering eradication …

Avermectin derivatives, pharmacokinetics, therapeutic and toxic dosages, mechanism of action, and their biological effects

G El-Saber Batiha, A Alqahtani, OB Ilesanmi, AA Saati… - Pharmaceuticals, 2020 - mdpi.com
Avermectins are a group of drugs that occurs naturally as a product of fermenting
Streptomyces avermitilis, an actinomycetes, isolated from the soil. Eight different structures …

[HTML][HTML] Effect of ivermectin on time to resolution of symptoms among adults with mild COVID-19: a randomized clinical trial

E López-Medina, P López, IC Hurtado, DM Dávalos… - Jama, 2021 - jamanetwork.com
Importance Ivermectin is widely prescribed as a potential treatment for COVID-19 despite
uncertainty about its clinical benefit. Objective To determine whether ivermectin is an …

Safety of high-dose ivermectin: a systematic review and meta-analysis

M Navarro, D Camprubí… - Journal of …, 2020 - academic.oup.com
Background Ivermectin is a key anthelmintic for the control of neglected tropical diseases.
The main indications for population-level control with ivermectin through mass drug …

Antiviral effect of high-dose ivermectin in adults with COVID-19: a proof-of-concept randomized trial

A Krolewiecki, A Lifschitz, M Moragas, M Travacio… - …, 2021 - thelancet.com
Background There are limited antiviral options for the treatment of patients with COVID-19.
Ivermectin (IVM), a macrocyclic lactone with a wide anti-parasitary spectrum, has shown …

Nitazoxanide/azithromycin combination for COVID-19: A suggested new protocol for early management

MT Kelleni - Pharmacological research, 2020 - Elsevier
Azithromycin has been shown to have a clinical efficacy against severe acute respiratory
syndrome coronavirus 2; ivermectin has also demonstrated a remarkable experimental …

The public health control of scabies: priorities for research and action

D Engelman, PT Cantey, M Marks, AW Solomon… - The Lancet, 2019 - thelancet.com
Scabies is a parasitic disease of the skin that disproportionately affects disadvantaged
populations. The disease causes considerable morbidity and leads to severe bacterial …

Ivermectin, a potential anticancer drug derived from an antiparasitic drug

M Tang, X Hu, Y Wang, X Yao, W Zhang, C Yu… - Pharmacological …, 2021 - Elsevier
Ivermectin is a macrolide antiparasitic drug with a 16-membered ring that is widely used for
the treatment of many parasitic diseases such as river blindness, elephantiasis and scabies …

The need for new vector control approaches targeting outdoor biting Anopheline malaria vector communities

S Sougoufara, EC Ottih, F Tripet - Parasites & Vectors, 2020 - Springer
Since the implementation of Roll Back Malaria, the widespread use of insecticide-treated
nets (ITNs) and indoor residual spraying (IRS) is thought to have played a major part in the …

[HTML][HTML] Efficacy and risk of harms of repeat ivermectin mass drug administrations for control of malaria (RIMDAMAL): a cluster-randomised trial

BD Foy, H Alout, JA Seaman, S Rao, T Magalhaes… - The Lancet, 2019 - thelancet.com
Background Ivermectin is widely used in mass drug administrations for controlling neglected
parasitic diseases, and can be lethal to malaria vectors that bite treated humans. Therefore …