Protein engineering through directed evolution and (semi) rational design has become a
powerful approach for optimizing and enhancing proteins with desired properties. The …

Peptides are bioactive molecules whose functional versatility in living organisms has led to
successful applications in diverse fields. In recent years, the amount of data describing …

With their diverse biological activities, peptides are promising candidates for therapeutic
applications, showing antimicrobial, antitumour and hormonal signalling capabilities …

Highly controlled synthesis of upconversion nanoparticles (UCNPs) can be achieved in the
heterogeneous design, so that a library of optical properties can be arbitrarily produced by …

Peptides have attracted attention during the last decades due to their extraordinary
therapeutic properties. Different computational tools have been developed to take …

Computational methods in protein engineering often require encoding amino acid
sequences, ie, converting them into numeric arrays. Physicochemical properties are a …

Background Accurate prognostic prediction plays a crucial role in the clinical setting.
However, the TNM staging system fails to provide satisfactory individual survival prediction …

Dengue fever is one of the most widespread vector-borne viral infections in the world,
resulting in increased socio-economic burden. WHO has reported that 2.5 billion people are …

Predicting the affinity between two proteins is one of the most relevant challenges in
bioinformatics and one of the most useful for biotechnological and pharmaceutical …

Introduction Osteoporosis, characterized by low bone mineral density (BMD), is an
increasingly serious public health issue. So far, several traditional regression models and …