Tracking mitochondrial Cu (I) fluctuations through a ratiometric fluorescent probe in AD model cells: Towards understanding how AβOs induce mitochondrial Cu (I) …
Q Zhao, L Ma, S Chen, L Huang, G She, Y Sun, W Shi… - Talanta, 2024 - Elsevier
Mitochondrial copper signaling pathway plays a role in Alzheimer's disease (AD), especially
in relevant Amyloid-β oligomers (AβOs) neurotoxicity and mitochondrial dysfunction …
in relevant Amyloid-β oligomers (AβOs) neurotoxicity and mitochondrial dysfunction …
Nanoparticle-conjugated nutraceuticals exert prospectively palliative of amyloid aggregation
KR Kanubaddi, SH Yang, LW Wu, CH Lee… - International Journal of …, 2018 - Taylor & Francis
Alzheimer's disease (AD), an age-related neurodegenerative disease, the most common
causes of dementia is a multifactorial pathology categorized by a complex etiology …
causes of dementia is a multifactorial pathology categorized by a complex etiology …
Electrostatic assembly of gold nanoparticle and metal–organic framework nanoparticles attenuates amyloid β aggregate-mediated neurotoxicity
L Yang, Y Chen, Z Jia, X Yuan, J Liu - Journal of Materials Chemistry B, 2023 - pubs.rsc.org
The deposition of amyloid β (Aβ) is a conventional pathological hallmark of Alzheimer's
disease (AD). Consequently, the inhibition of Aβ aggregation combined with the …
disease (AD). Consequently, the inhibition of Aβ aggregation combined with the …
Amyloid-beta impairs TOM1-mediated IL-1R1 signaling
A Cadete Martini, A Gomez-Arboledas… - Proceedings of the …, 2019 - National Acad Sciences
Defects in interleukin-1β (IL-1β)–mediated cellular responses contribute to Alzheimer's
disease (AD). To decipher the mechanism associated with its pathogenesis, we investigated …
disease (AD). To decipher the mechanism associated with its pathogenesis, we investigated …
Protect effects of seafood-derived plasmalogens against amyloid-beta (1–42) induced toxicity via modulating the transcripts related to endocytosis, autophagy …
J Feng, G Song, Q Shen, X Chen, Q Wang… - Frontiers in aging …, 2021 - frontiersin.org
To investigate the underlying mechanisms of decreased plasmalogens (Pls) levels in
neurodegenerative diseases, here the effects of seafood-derived Pls on undifferentiated and …
neurodegenerative diseases, here the effects of seafood-derived Pls on undifferentiated and …
[HTML][HTML] Upregulation of endocytic protein expression in the Alzheimer's disease male human brain
M Alsaqati, RS Thomas, EJ Kidd - Aging Brain, 2023 - Elsevier
Amyloid-beta (Aβ) is produced from amyloid precursor protein (APP) primarily after APP is
internalised by endocytosis and clathrin-mediated endocytic processes are altered in …
internalised by endocytosis and clathrin-mediated endocytic processes are altered in …
Amyloid-β peptides disrupt interactions between VAMP-2 and SNAP-25 in neuronal cells as determined by FRET/FLIM
Background: Synaptic dysfunction prevalent in Alzheimer's disease (AD) brain is closely
associated with increased accumulation of amyloid-β (Aβ) peptides in the brain …
associated with increased accumulation of amyloid-β (Aβ) peptides in the brain …
Evidence that brain-reactive autoantibodies contribute to chronic neuronal internalization of exogenous amyloid-β 1-42 and key cell surface proteins during …
EL Goldwaser, NK Acharya, H Wu… - Journal of …, 2020 - content.iospress.com
Blood-brain barrier (BBB) permeability is a recognized early feature of Alzheimer's disease
(AD). In the present study, we examined consequences of increased BBB permeability on …
(AD). In the present study, we examined consequences of increased BBB permeability on …
The CHD family chromatin remodeling enzyme, Kismet, promotes both clathrin-mediated and activity-dependent bulk endocytosis
EL Hendricks, FLW Liebl - Plos one, 2024 - journals.plos.org
Chromodomain helicase DNA binding domain (CHD) proteins, including CHD7 and CHD8,
remodel chromatin to enable transcriptional programs. Both proteins are important for proper …
remodel chromatin to enable transcriptional programs. Both proteins are important for proper …
Amyloid-beta peptides 40 and 42 employ distinct molecular pathways for cell entry and intracellular transit at the BBB endothelium
Blood-brain barrier (BBB) is a critical portal regulating the bidirectional transport of amyloid
beta (Aβ) proteins between blood and brain. Disrupted trafficking at the BBB may not only …
beta (Aβ) proteins between blood and brain. Disrupted trafficking at the BBB may not only …