Interleukin-6 in neuromyelitis optica spectrum disorder pathophysiology

K Fujihara, JL Bennett, J de Seze… - Neurology …, 2020 - AAN Enterprises
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disorder that
preferentially affects the spinal cord and optic nerve. Most patients with NMOSD experience …

Hope for patients with neuromyelitis optica spectrum disorders—from mechanisms to trials

SJ Pittock, A Zekeridou, BG Weinshenker - Nature Reviews Neurology, 2021 - nature.com
Neuromyelitis optica spectrum disorder (NMOSD) is a rare inflammatory CNS disease that
primarily manifests as relapsing episodes of severe optic neuritis and myelitis. Diagnosis of …

[HTML][HTML] Trial of satralizumab in neuromyelitis optica spectrum disorder

T Yamamura, I Kleiter, K Fujihara… - … England Journal of …, 2019 - Mass Medical Soc
Background Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease of
the central nervous system and is associated with autoantibodies to anti–aquaporin-4 …

New therapies for neuromyelitis optica spectrum disorder

M Levy, K Fujihara, J Palace - The Lancet Neurology, 2021 - thelancet.com
Background Neuromyelitis optica spectrum disorder is an autoimmune disease of the CNS
that primarily affects the optic nerves and spinal cord. Most patients have serum antibodies …

Effects of neuromyelitis optica–IgG at the blood–brain barrier in vitro

Y Takeshita, B Obermeier, AC Cotleur… - Neurology …, 2016 - AAN Enterprises
Objective: To address the hypothesis that physiologic interactions between astrocytes and
endothelial cells (EC) at the blood–brain barrier (BBB) are afflicted by pathogenic …

Th17 cells pathways in multiple sclerosis and neuromyelitis optica spectrum disorders: pathophysiological and therapeutic implications

GRD Passos, DK Sato, J Becker… - Mediators of …, 2016 - Wiley Online Library
Several animal and human studies have implicated CD4+ T helper 17 (Th17) cells and their
downstream pathways in the pathogenesis of central nervous system (CNS) autoimmunity in …

Treatment of neuromyelitis optica spectrum disorder: acute, preventive, and symptomatic

RA Kessler, MA Mealy, M Levy - Current treatment options in neurology, 2016 - Springer
Opinion statement Neuromyelitis optica spectrum disorder (NMOSD) is a rare, autoimmune
disease of the central nervous system that primarily attacks the optic nerves and spinal cord …

A comprehensive review of the advances in neuromyelitis optica spectrum disorder

P Siriratnam, S Huda, H Butzkueven… - Autoimmunity …, 2023 - Elsevier
Neuromyelitis optica spectrum disorder (NMOSD) is a rare relapsing neuroinflammatory
autoimmune astrocytopathy, with a predilection for the optic nerves and spinal cord. Most …

[HTML][HTML] Regulatory impairment in untreated Parkinson's disease is not restricted to Tregs: other regulatory populations are also involved

DD Álvarez-Luquín, A Arce-Sillas… - Journal of …, 2019 - Springer
Background Parkinson's disease (PD) is the second most common neurodegenerative
disease in the world. Various studies have suggested that the immune response plays a key …

Progress in treatment of Neuromyelitis Optica Spectrum Disorders (NMOSD): Novel insights into therapeutic possibilities in NMOSD

M Shi, F Chu, T Jin, J Zhu - CNS Neuroscience & Therapeutics, 2022 - Wiley Online Library
Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune inflammatory
demyelinating disorder of the central nervous system (CNS), which is a severely disabling …