Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

▪ Abstract Activity-dependent changes in synaptic function are believed to underlie the
formation of memories. Two prominent examples are long-term potentiation (LTP) and long …

Excitatory synapses in the CNS release glutamate, which acts primarily on two types of
ionotropic receptors: AMPA receptors and NMDA receptors. AMPA receptors mediate the …

The AMPA receptor (AMPAR) GluR2 subunit dictates the critical biophysical properties of the
receptor, strongly influences receptor assembly and trafficking, and plays pivotal roles in a …

Ionotropic neurotransmitter receptors mediate rapid synaptic transmission in the CNS and
PNS. Owing to this central role in trans-synaptic signal transduction, modulation of these …

Drugs of abuse induce long-lasting changes in neural circuits that may underlie core
components of addiction. Here we focus on glutamatergic synapses onto dopamine (DA) …

Brain development, sensory information processing, and learning and memory processes
depend on Hebbian forms of synaptic plasticity, and on the remodeling and pruning of …

AMPA-receptor (AMPAR) transport to synapses plays a critical role in the modulation of
synaptic strength. We show that the functionally critical GluR2 subunit stably resides in an …

Dynamic regulation of synaptic efficacy is one of the mechanisms thought to underlie
learning and memory. Many of the observed changes in efficacy, such as long-term …