Heat shock proteins (HSPs) constitute a large family of molecular chaperones classified by
their molecular weights, and they include HSP27, HSP40, HSP60, HSP70, and HSP90 …

Heat shock protein 90, also known as Hsp90, is an extensively preserved molecular
chaperone that performs a critical function in organizing various biological pathways and …

Protein homeostasis, an important aspect of cellular fitness that encompasses the balance of
production, folding and degradation of proteins, has been linked to several diseases of the …

Abstract Long noncoding RNA KCNQ1OT1 participates in the regulation of imprinted genes
within the kcnq1 domain. But its roles in carcinogenesis and metastasis remain largely …

Oncogenic client-proteins of the chaperone Heat shock protein 90 (HSP90) insure unlimited
tumor growth and are involved in resistance to chemo-and radiotherapy. The HSP90 …

Hepatocellular carcinoma (HCC) is a highly malignant tumor that responds very poorly to
existing therapies, most probably due to its extraordinary inter‐and intra‐tumor molecular …

While cells from multicellular organisms are dependent upon exogenous signals for their
survival, growth, and proliferation, commitment to a specific cell fate requires the correct …

Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin
lymphoma in adults, exhibiting highly heterogenous clinical behavior and complex …

Background Lung adenocarcinoma (LUAD) is one of the major types of lung cancer with
high morbidity and mortality. The TRAF-interacting protein (TRAIP) is a ring-type E3 ubiquitin …

Small cell lung cancer (SCLC) is an aggressive malignant tumour which accounts for
approximately 13–15% of all newly diagnosed lung cancer cases. To date, platinum-based …