The widely varying different approaches to the total synthesis of the indoloquinoline alkaloid
neocryptolepine are discussed. Aspects relating to the isolation of the natural product from …

One of the main problems of Chagas disease (CD), the parasitic infection caused by
Trypanosoma cruzi, is the lack of a completely satisfactory treatment, which is currently …

For six random splits, one‐variable models of rat toxicity (minus decimal logarithm of the
50% lethal dose [pLD50], oral exposure) have been calculated with CORAL software …

Background Chagas disease is a neglected tropical disease (NTD) caused by the eukaryotic
parasite Trypanosoma cruzi. The current clinical and preclinical pipeline for T. cruzi is …

Hepatitis C constitutes an unresolved global health problem. This infectious disease is
caused by the hepatotropic hepatitis C virus (HCV), and it can lead to the occurrence of life …

Despite the tremendous improvement in overall global health heralded by the adoption of
the Millennium Declaration in the year 2000, tropical infections remain a major health …

A drug company has to ensure the quality, safety, and efficacy of a marketed drug by
subjecting the drug to a variety of tests [1]. Therefore, drug development is a time-consuming …

There are many drugs described with very different affinity to a large number of receptors. In
this work, we selected Drug-Target pairs (DTPs/nDTPs) of drugs with high affinity/non-affinity …

Plants are one of the most important resources for the discovery of new drugs. The potential
of natural compounds as new drug leads is clearly illustrated by the discovery and …

The protozoan diseases leishmaniasis, human African trypanosomiasis (HAT) and Chagas
disease (CD) are responsible for substantial global morbidity and mortality in tropical and …