The increasing lifespan in developed countries results in age-associated chronic diseases.
Biological aging is a complex process associated with accumulated cellular damage by …

HIV-associated neurocognitive disorder (HAND) is characterized by cognitive and
behavioral deficits in people living with HIV. HAND is still common in patients that take …

Synaptodendritic injury is thought to underlie HIV-associated neurocognitive disorders and
contributes to exaggerated inflammation and cognitive impairment seen in opioid abusers …

Epileptogenesis is a dynamic process initiated by insults to brain and commonly
accompanied by cognitive impairment. Isoliquiritigenin (ISL), a flavonoid in licorice, has a …

Background Oxidative stress and neuroinflammation are central pathogenic mechanisms
common to many neurological diseases. Isoliquiritigenin (ISL) is a flavonoid in licorice with …

Background Some evidence suggests that cannabidiol (CBD) has potential to help alleviate
HIV symptoms due to its antioxidant and anti-inflammatory properties. Here we examined …

Background Synaptodendritic damage is a pathological hallmark of HIV-associated
neurocognitive disorders, and HIV-1 Tat protein is known to cause such injury in the central …

Antiretroviral therapy has dramatically improved the lives of human immunodeficiency virus
1 (HIV-1) infected individuals. Nonetheless, HIV-associated neurocognitive disorders …

HIV-1 associated neurocognitive deficits are increasing in prevalence, although the
neuronal basis for these deficits is unclear. HIV-1 Tg rats constitutively express 7 of 9 HIV …

Motivational alterations, such as apathy, in HIV-1+ individuals are associated with
decreased performance on tasks involving frontal-subcortical circuitry. We used the HIV-1 …