Simple Summary Anaplastic thyroid carcinoma (ATC) has a dismal prognostic.
Chemotherapy and radiotherapy are the mainstem options for patients with ATC. In selected …

Most malignant thyroid tumours are initially treated with surgery or a combination of surgery
and radioactive iodine (RAI) therapy. However, in patients with metastatic disease, many …

Understanding of dedifferentiation, an indicator of poo prognosis for patients with thyroid
cancer, has been hampered by imprecise and incomplete characterization of its …

Tumours can arise from thyroid follicular cells if they acquire driver mutations that
constitutively activate the MAPK signalling pathway. In addition, a limited set of additional …

Differentiated thyroid cancers (DTCs) are primarily initiated by mutations that activate the
MAPK signaling cascade, typically at BRAF or RAS oncoproteins. DTCs can evolve to more …

Simple Summary Anaplastic thyroid carcinoma (ATC) is a tumor with exceedingly high
mortality rates, and current treatment options are very limited once the disease has spread …

The genetics underlying thyroid cancer dedifferentiation is only partly understood and has
not yet been characterised using comprehensive pan‐genomic analyses. We investigated a …

Background Thyroid cancer is the most common type of endocrine malignancy and the
incidence rate is rapidly increasing worldwide. Epigallocatechin-3-gallate (EGCG) could …

Well-differentiated thyroid carcinoma has a favorable prognosis with a 5-year survival rate of
over 95%. However, the undifferentiated or anaplastic type accounting for< 0.2%, usually in …

Intratumoral heterogeneity (ITH) refers to a subclonal genetic diversity observed within a
tumor. ITH is the consequence of genetic instability and accumulation of genetic alterations …