Background Developmental Defects of Enamel (DDE) is a pathology of the teeth that can
greatly alter the quality of life of patients (hypersensitivity, esthetic issues, loss of function …

Cathepsin C (CTSC) is a lysosomal cysteine protease constitutively expressed at high levels
in the lung, kidney, liver, and spleen. It plays a key role in the activation of serine proteases …

Amelogenesis imperfecta (AI) is a heterogeneous group of genetic rare diseases disrupting
enamel development (Smith et al., Front Physiol, 2017a, 8, 333). The clinical enamel …

Rare genetic diseases are difficult to diagnose and this translates in patient's diagnostic
odyssey! This is particularly true for more than 900 rare diseases including orodental …

Bullying occurs when an individual is repeatedly victimised by negative actions performed
by peers. As oral features, like malocclusion and dental structural defects, can promote …

The development of tooth is a highly complex procedure and mastered by specific genetic
programs. Genetic alterations, environmental factors, and developmental timing can disturb …

Background Multiple signaling molecules have been shown to play crucial roles in dental
root development. Therefore, we aimed to investigate the prevalence of S-shaped roots and …

The field of primary immunodeficiencies (PIDs) is rapidly evolving. Indeed, the number of
described diseases is constantly increasing thanks to the rapid identification of novel genetic …

Craniofacial and jaw bones have unique physiological specificities when compared to axial
and appendicular bones. However, the molecular profile of the jaw osteoblast (OB) remains …

Abstract Background/Objectives Tooth agenesis (TA) is among the most common
malformations in humans. Although several causative mutations have been described, the …