Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Cellular senescence was first described by Hayflick and Moorhead in the 1960s as the
irreversible arrest of cells following prolonged cultivation. Telomere shortening is the key …

Glutathione (GSH) protects against oxidative damage in many tissues, including retinal
pigment epithelium (RPE). Oxidative stress-mediated senescence and death of RPE and …

An increase in life expectancy in developed countries has led to a surge of chronic aging-
related diseases. In the last few decades, several studies have provided evidence of the …

Normal cells can permanently lose the ability to proliferate when challenged by potentially
oncogenic stress, a process termed cellular senescence. Senescence-associated beta …

Loss of functionality during aging of cells and organisms is caused and accompanied by
altered cell-to-cell communication and signalling. One factor thereby is the chronic …

This article provides an overview of the role of oxygen in wound healing. The understanding
of this role has undergone a major evolution from its long-recognized importance as an …

Ageing is influenced by the intrinsic disposition delineating what is maximally possible and
extrinsic factors determining how that frame is individually exploited. Intrinsic and extrinsic …

Publikace je určena kromě geriatrů zejména internistům a praktickým lékařům, užitečná je v
běžné praxi i v postgraduálním studiu. Kniha vymezuje geriatrického nemocného, popisuje …

Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial pneumonia of unknown
cause with a median survival of only three years. Little is known about the mechanisms that …