The corpus luteum (CL) is one of the few endocrine glands that forms from the remains of
another organ and whose function and survival are limited in scope and time. The CL is the …

The WGATAR motif is a common nucleotide sequence found in the transcriptional regulatory
regions of numerous genes. In vertebrates, these motifs are bound by one of six factors …

Spermatogenesis is a complex and dynamic cellular differentiation process critical to male
reproduction and sustained by spermatogonial stem cells (SSCs). Although patterns of gene …

Abstract Follicle-stimulating hormone (FSH), a pituitary glycoprotein hormone, is an integral
component of the endocrine axis that regulates gonadal function and fertility. To transmit its …

Transcription factor GATA4 is expressed in Sertoli and Leydig cells and is required for
proper development of the murine fetal testis. The role of GATA4 in adult testicular function …

Spermatogonial stem cells (SSCs) maintain spermatogenesis throughout adulthood through
balanced self-renewal and differentiation, yet the regulatory logic of these fate decisions is …

We have sought to identify transcriptional pathways in adipogenesis using an integrated
experimental and computational approach. Here, we employ high-throughput DNase …

Defining how genes get turned on and off in a correct spatiotemporal manner is integral to
our understanding of the development, differentiation, and function of different cell types in …

Transcription factor GATA4 is expressed in somatic cells of the mammalian testis. Gene
targeting studies in mice have shown that GATA4 is essential for proper differentiation and …

Conditional deletion of Gata4 in Sertoli cells (SCs) of adult mice has been shown to increase
permeability of the blood-testis barrier (BTB) and disrupt spermatogenesis. To gain insight …